A big medical oncology love-in in the GU Cast studio today!! Professor Enrique Grande was visiting from MD Anderson Cancer Centre in Madrid to chat all about some of the sensational advances we have seen in metastatic bladder cancer in recent times. And we were also joined by old friend Professor Andrew Weickhardt from Austin Health in Melbourne to educate ourselves on what is an antibody drug conjugate and how does EV work. Plus lots of laughter!!

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Axel Merseburger (Chief and Professor of Urology, Lubeck, Germany) was in Australia recently and popped into the GU Cast studio for a chat. Axel was at the USANZ ASM recently and also on a speaker tour supported by Janssen Pharmaceuticals, so we put together this Themed Podcast to pick his brains on high-risk prostate cancer and mHSPC in 2024.
This Themed Podcast is supported by Janssen Pharmaceuticals, Gold Partners of GU Cast. 

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Declan and Renu bring you lots of highlights and interviews from the Urological Society of Australia & New Zealand (USANZ) Annual Scientific Meeting (ASM) which took place last week in Adelaide. Almost 1000 delegates descended on this beautiful part of the world, famous for its beaches and wineries.
Hear from Robert Nam, Paul Anderson, Nathan Lawrentschuk, Alan McNeill, Axel Merseburger, Dixon Woon, Michael Choong, Jo Cresswell, Anthony Ta, and Shane La Bianca who is Convenor of #USANZ25. 
GU Cast Conference Highlights are supported by Bayer Pharmaceuticals (China), GU Cast Conference Highlights Partner.
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Needle through the rectum or needle through the skin?? Transrectal vs transperienal prostate biopsy is certainly a hot topic in prostate cancer, with the vast majority of men having their biopsy through the rectum rather than through the skin. It is quick, cheap and easy (for the urologist and the health system), but leaves the patient at risk of serious harm from infectious complications, at least according to historic reports.
Today Declan and Renu chat with Dr Jim Hu, Urologist at Cornell University in New York, and leader of the PREVENT trial, a randomised study of transrectal vs transperineal biopsy which has just been published in European Urology. We are also joined by Associate Professor Jeremy Grummet, Urologist at Alfred Health in Melbourne, and long-time advocate of transperineal biopsy. Did this trial finally establish transperineal as the new standard of care for men undergoing prostate biopsy?? Tune in to find out!

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Links:
PREVENT trial in European Urology 

Two of the highest profile presentations at the recent ASCO GU Meeting were the plenary presentations of the CONTACT 02 trial, and the Keynote-564 trial. Generally speaking, these were well received; indeed quite enthusiastically received in some quarters! Not however in the quarter of prolific oncology commentator and Haematologist/Oncologist & Professor of Epidemiology,  Dr Vinay Prasad! “Unethical” and “sh**ty” are just some of the terms he used to describe these in two episodes of his podcast, “Plenary Session”. Declan and Renu take Vinay to task for some of the somewhat personal attacks he makes on colleagues, but do enjoy listening to his critique, and indeed agree with many of his points! 

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Links:
Plenary Session podcast on Contact 02
Plenary Session podcast on Keynote-564
Dr Vinay Prasad Twitter 

Renu caught up with lots of experts and friends at ASCO GU in San Francisco recently and brings you all the highlights. Hear from Toni Choueiri, Matt Cooperberg (on that debate on renaming low-grade prostate cancer), Todd Morgan, Neha Vapiwala, Morgan Roupret, Sophia Kamran, Morgan Roupret, Sam Washington, plus a great chat with Tyler Seibert while they were out for an early morning run around beautiful San Francisco.
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GU Cast Conference Highlights are supported by our Gold Partner, Bayer China. 

For all you enthusiasts of PSMA theranostics, we bring you another one of our fabulous ProsTIC/Prostate Cancer Foundation Global Webinars with some of the best minds in the business. This is the eighth of our collaborative webinars over the past four years and the focus today is bringing lutetium PSMA earlier in prostate cancer.

Two keynote lectures from Dr Oliver Sartor (Mayo Clinic) and Professor Louise Emmett (St Vincent's. Sydney)set the scene, focusing on brand-new data from the PSMAfore  and Enza-P trials. We have an Asia-Pacific focus with a superb range of multidisciplinary panellists from across the region.

Co-Hosted by GU Cast’s own Dr Renu Eapen with Professor Michael Hofman from ProsTIC/Peter MacCallum Cancer Centre. They are joined in studio by friends of the podcast Dr Louise Kostos and Dr James Buteau.

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A must listen (actually a must WATCH!!) episode of GU Cast if you have any experience with the side-effects of treatment of prostate cancer. Whether you are a patient or loved one, or a surgeon/radiation oncologist/medical oncologist, or a nurse or allied health professional - then this is for you.
Declan and Renu chat about "A Touchy Subject" with the wonderful Victoria Cullen.

This one much better enjoyed on our YouTube channel!

Links:
A Touchy Subject 

We reveal the three winners of our APCCC Travel Awards 2024! These three trainees will be heading off to Lugano for the world's best prostate cancer meeting which takes place from 25-27 April on the shores of Lake Lugano.

A perennial topic on GU Cast!! But today we welcome a couple of very useful papers in European Urology Oncology which help us understand how PSMA PET/CT can help patient selection for pelvic lymph node dissection in prostate cancer. We are joined by Dr Giorgio Gandaglia from San Raffaele Hospital in Milano to discuss these two papers (links below).
We also hear about Declan's recent trip to San Raffaele as Visiting Professor, and he sits down for a wide-ranging chat with professor Francesco Monitorsi, Director & Professor of Urology at San Raffaele.

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Links:
Can PSMA reduce PLND? A systematic review

Optimal use of PSMA to select patients for PLND. Updated validation of the Briganti and MSKCC nomograms