Dr Ashish Kamat (MD Anderson Cancer Centre, Houston),  joins Declan and Renu to discuss a very nice paper recently published in European Urology Oncology overviewsing the role of lymph node dissection (LND) in GU oncology. Really nice piece of work led by Dr Amanda Myers along with a bunch of well known names in urologic oncology. A very succinct summary of LND in bladder, upper tract urothelial, renal, prostate, penile and testicular cancer. Check out the link below to find the full paper

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Links
Myers et al paper 

It has becoming a familiar refrain around the world , and is certainly good news for the prostate cancer community! This week, another androgen receptor pathway inhibitor (ARPI) became reimbursed for men with hormone-sensitive metastatic prostate cancer (mHSPC) in Australia. Darolutamide is already available for men with non-metastatic castration-resistant prostate cancer, and is now also available for men with mHSPC in combination with androgen deprivation therapy and chemotherapy. Therefore we continue on our mission at GU Cast to educate ourselves about the use of ARPIs in mHSPC. And yes, even simple urologists like us can get up to speed with these drugs!
Declan and Renu are joined by fellow Urologist Associate Professor Joseph Ischia, one of our favourite prostate cancer experts. And a great podcaster himself! Check out the back catalogue of "Talking Urology" using the links below.
Plus what is a "jiffy stent"??? \
This Themed Podcast is supported by Bayer, Silver Partners of GU Cast.

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Link:
 https://www.talkingurology.com.au/

SABR supremos Piet Ost and Shankar Siva join us to discuss the management of lymph node-only recurrence following primary treatment of prostate cancer. And of course our resident PSMA PET/CT guru Michael Hofman also turned up as himself and Piet love debating the merits of PSMA!
How and when shoudl we image for biochemical recurrence? What are the limits of SABR? WHat about systemic therapy? It's all in this episode with great leaders in the field.
Recorded on site at Peter Mac on the fringe of the 2023 SABR Symposium. With your usual hosts Renu Eapen and Declan Murphy

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Prof Fred Saad (University of Montreal) drops in to chat about the interesting condition that is non-metastatic castration-resistant prostate cancer (nmCRPC). Which men are at risk of developing metastases? When should we use an AR pathway inhibitor? Why PSMA PET/CT should NOT be used. And hear his thoughts on "dabbling" in prostate cancer!
Also joined by Professor Shankar Siva and Dr Louise Kostos from Peter MacCallum Cancer Centre. Hosted as ever by Dr Renu Eapen and Professor Declan Murphy.
Fred was on a speaker tour in Australia supported by Bayer Pharmaceuticals and this Themed Podcast is supported by Bayer, Silver Partners of GU Cast.
Update  -  we mentioned that darolutamide was the only ARPI listed for reimbursement in Australia (true at time of recording). We can update that all TGA approved ARPIs for nmCRPC are now reimbursed in Australia.

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What a great ESMO for GU Oncology!! Declan caught up with some plenary speakers in Madrid to discuss the biggest topics. PSMA theranostics with Louise Emmett (ENZA-P) and Oliver Sartor (PSMAfore); ARPIs in biochemical recurrence with Steve Freedland (EMBARK), Morgan Roupret and Boris Hadaschik. Plus the latest negative immunotherapy trials in prostate cancer with Christian Gratzke.

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The LuTectomy trial has just been published in European Urology, and as the GU Cast team have been very much involved, we thought we should dive into the details on today's podcast. LuTectomy is a clinical trial to evaluate the role of 177-Lutetium-PSMA prior to radical prostatectomy. Declan is the study co-PI along with Professor Michael Hofman, and Renu is first author on the LuTectomy paper (and doing a PhD on it)! Plus, Professor Ken Herrmann from Essen has co-authored the accompanying Editorial in European urology and joins us for a discussion.

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Thanks to all the LuTectomy team and to all of our fantastic patients. And huge thanks to our funders.

Funding/Support:
This investigator-initiated study was funded by the Movember Foundation, the Australian Government Medical Research Future Fund (MRFF) with contribution from the EJ Whitten Foundation and Novartis.

Acknowledgements:
We thank the medical, surgical, nursing, nuclear medicine, and administrative staff of all the departments at the Peter MacCallum Cancer Centre who were involved in this trial. We thank the patients who agreed to participate in the study. PSMA-617 was supplied
 by Novartis and no carrier added 177Lu by the Australian Nuclear Science and Technology Organisation (ANSTO).
We remember and thank the late Dr John Violet for his involvement including study conception and design.

Links:
LuTectomy paper in European Urology
LuTectomy Editorial 

One of our most popular episodes in 2022 was "Patting the Hormone Therapy Shark" with author, surfer and prostate cancer survivor, Tim Baker. And a lot has happened in the 12 months since so we invited Tim back for a follow-up chat in this Themed Podcast supported by our GU Cast Gold Partners, Mundipharma.
Tim's inspiring approach to managing the side-effects of androgen deprivation therapy are well worth knowing for anyone involved in advanced prostate cancer including clinicians (especially clinicians!), nurses and allied health care professionals, industry, and of course patients and their loved ones. Tim runs through his "MEDS" strategy in this podcast, and also chats about other options including creative writing, the topic of his ongoing PhD.
Thanks to our friends at Mundipharma for their ongoing support for GU Cast through their Gold Partnership.

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Links:
Tim's website
Previous GU Cast episode 

We hijacked our good friends Professor Boris Hadaschik (Urologist, Essen, Germany), and Associate Professor Tyler Seibert (Radiation Oncologist, University of California, San Diego), who happened to be in Melbourne this week, and diverted them into the GU Cast studio for a chat about high-risk prostate cancer. Boris and Tyler were on a speaker tour supported Janssen Pharmaceuticals, so we put together this Themed Podcast supported by Janssen (Gold Partners of GU Cast), to probe three key questions in high-risk prostate cancer in 2023:
1. What is the role of PSMA PET/CT in initial staging?
2. If the PSMA PET/CT is N0, can we avoid pelvic lymph node dissection?
3. What is the optimal radiotherpay strategy for high-risk prostate cancer in 2023?
Superb multidisciplinary chat with two great experts. Thanks to Janssen for their support for this Themed Episode of GU Cast.

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Twitter links:
Boris Hadaschik
Tyler Seibert 

The European Association of Nuclear Medicine (EANM) Annual Meeting is the World's leading nuclear medicine extravaganza! Today we cross live to Professor Michael Hofman and friends to hear some of the GU highlights at this year's annual meeting in Vienna.  Michael is joined by Prof Ken Herrmann, Dr Kerry Jewell, Dr Francesco Ceci, Dr Phiilip Kuo, Dr Bastiaan Privé and Dr Wolfgang Fendler. A fantastic update from EANM in Vienna!

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The mass media were quick to pick up on two papers in JAMA Surgery last week with headlines such as "Patients have better outcomes with female surgeons", and "Should you pick the sex of your surgeon?". So what's it all about??
We chat with lead author of one of these papers. Dr Chris Wallis, Urologist at the University of Toronto, whose looked at outcomes for more than 1.2 million (!!) patients undergoing a range of surgery types, and showed that patients operated on by female surgeons had less complications and better survival. Another study from Sweden showed similar benefits in patients undergoing gallbladder surgery.
Chris tells us more. Plus Aoife McVey brings us some great social media highlights this week. 

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Article Links:
Chris Wallis et al paper
Swedish study on gallbladder surgery
Guardian Newspaper article

Twitter Links:
Fun at the EUREP Meeting courtesy of Uros Milenkovoic
Kim Kardashian in an MRI scanner
Rhea Liang weighs in on ortho comments
David Canes explains bladder diverticulum 3

David Canes Youtube channel