When Iran recently launched more than three hundred drones, ballistic missiles, and cruise missiles in a large-scale attack against Israel, almost every single one was stopped from reaching its target. A combination of ground-based air defenses, ship-launched weapons, and aircraft from multiple nations were involved in the defensive operation. But how does such a complex air defense mission happen? How is it commanded and controlled? How are the differing capabilities of such a variety of air defense systems integrated most effectively? And what lessons can be derived from the Iranian attack and the successful defense to inform the way the United States and its partners and allies conceptualize and implement defenses against a rapidly evolving air and missile threat?