It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification).

What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode for you! Check out our prep notes (including for this episode) here. 

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It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice.

Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our prep notes (including for this episode) here. 

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders. 

We did it. We got to the end. 

Nonfermentors... Nobbled. 

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Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state.

Final article here:
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.
PMID: 38244557.
https://doi.org/10.1016/S1473-3099(23)00756-9

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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JOURNAL CLUB, YO, IT’S A SABATO!!!

Join Jame and Callum as we travel back in time to when we recorded this deep dive into the SABATO trial pre-print, now peer-reviewed and published in the Lancet ID!

In the next episode we'll give a little update as to how the final article differs from the preprint (not much).

We also talked about in our FIS Highlights Episode 3.

We loved this trial and we hope you’ll all give it a read, it’s well worth it!

Article here:
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.
PMID: 38244557.
https://doi.org/10.1016/S1473-3099(23)00756-9

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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In this penultimate episode in the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the regionally important neglected tropical disease Melioidosis, caused by Burkholderia pseudomallei.

This episode was based disproportionately on the following article, and we extend our thanks to the authors for thoughfully publishing it so close to us wanting to do a podcast episode on Melioid!

Meumann, E.M., Limmathurotsakul, D., Dunachie, S.J. et al. Burkholderia pseudomallei and melioidosis. Nat Rev Microbiol (2023).

https://www.melioidosis.info/

Link to prep notes here.

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In this Episode, Callum reflect on his recent runaway success passing the FRCPath Part 2, passes on some tips and tricks for the exam, and then we talk about what 3 antibiotics we would take with us to a Desert Island (that has all pathogens and environments where you would find said pathogens, so not just a desert apparently).

'Prepping to Pass' episodes mentioned: 40, 42, 43 & 50.

The Table and Links mentioned in this episode can be found here: https://idiots.notion.site/70-Reflections-on-Part-2-2023-a193fd830c9b4d6c9381107471fcdbca

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How do you think about antibiotics?

This Christmas we give the best gift of all: no puns in an episode.
Join Jame and Callum as they talk about a method for thinking about and explaining antibiotics.

Here are the show notes for this episode: https://idiots.notion.site/69-Choosing-an-antimicrobial-4e7446a91ff6413aa14924a2ba905ffa 

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Did you think the  evidence base for Stenotrophomonas was bad? Well allow  us to introduce you to Burkholderia cepacia complex!

BCC is pretty niche but a key pathogen in people living with cystic fibrosis. We talk through the (very) limited treatment options and evidence base for this difficult bug.

Prep notes for this episode here: https://idiots.notion.site/68-Burkholderia-cepacia-complex-7bba8a7c74df490cb2e91d087a3cdb2a

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Callum and Jame wrap up their thoughts on the recent FIS conference. 

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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