In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, finishes educating Callum and Jame (mostly Callum) on the concept of Microbiotoxicity!

This episode is part 2 of 2. Here we discuss: 

- What is microbiotoxicity?
- Risk factors for microbiotoxicity
- Which antibiotics are associated with microbiotoxicity?
- Mitigating microbiotoxicity

https://www.researchgate.net/profile/Anastasia-Theodosiou

https://x.com/doctoranastasia

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In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, returns to talk about her favourite subject! 

This episode is part 1 of 2. Here we discuss: 
- What is the microbiome
- Viewing the microbiome as an organ system
- The microbiome's association with disease
- How we study the microbiome

Stay tuned for part 2 (in 1-2 weeks depending on editing), when we talk about the effect of medicine on the microbiome, microbiotoxicity, and what you can do to keep your patients' microbiomes in tip top shape! 

https://www.researchgate.net/profile/Anastasia-Theodosiou

https://x.com/doctoranastasia

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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Join us for this special 80th episode celebrating Jame's favourite trial.

https://www.nejm.org/doi/full/10.1056/NEJMoa1808312

Prep notes (including the images referred to in the poem) here. 

Special thanks to the Wikiguidelines Endocarditis crew for their work summarising the evidence this poem was based on. 

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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Presenting: More on Penicillin-Binding-Proteins than you realistically ever need to know! 

• What is the difference between Gram positive and negative bacteria's cell walls?
• What is a Penicillin Binding Protein (PBP)?
• Why are they called PBPs?
• What do PBPs do?
• What makes MRSA resistant to (most) beta-lactams?

These any many more questions answered!

Notion page here - you'll need it for this one, check it out! 

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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One PK table to rule them all
One table to find them
One table to bring them all
And in the darkness blind them…

…with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike!

Prep notes here. 

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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The last Pharmacokinetics episode had finally been …Excreted!
 
 This episode  covers the ‘drug out’ bit of pharmacokinetics, including things such as:
 
 -What is clearance?
 -how to calculate half life
 and
 -doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up).
 
 Check out our prep notes (including for this episode) here. 

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification).

What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode for you! Check out our prep notes (including for this episode) here. 

Support the show

Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice.

Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our prep notes (including for this episode) here. 

Support the show

Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders. 

We did it. We got to the end. 

Nonfermentors... Nobbled. 

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state.

Final article here:
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.
PMID: 38244557.
https://doi.org/10.1016/S1473-3099(23)00756-9

Support the show

Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

If you are enjoying the podcast please leave a review on your preferred podcast app!

Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod