The most played episodes among Podcast App listeners.

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   Number 1: A new era for type 1 diabetes treatment

   Insulin has been used to treat type 1 diabetes for more than a century but now there is a new treatment being rolled out on the NHS that can delay the onset of the disease for years. Alongside, screening is gathering pace, identifying those that could benefit. So, is this the beginning of a new era for type 1 diabetes treatment? Dima and his mum Elena explain what it was like to be told that he had tested positive for developing type 1 diabetes and what it was like taking part in the trial for this new drug, teplizumab. Parth Narendran, a Professor of Diabetes Medicine at the University of Birmingham, and Consultant Paediatric Endocrinologist Dr Renuka Dias at Birmingham Women's and Children's Hospital, reveal how these changes are transforming treatment. In July, the NHS announced plans to incentivise us to walk a marathon a month by offering vouchers and discounts. But with scant detail on how the plan will actually work, we ask Joan Costa-i-Font, Professor of Health Economics at London School of Economics, what makes schemes like this succeed or fail. Plus, why are horse fly bites so painful? Dr Erica McAlister, an entomologist at the Natural History Museum, explains how the flies break into our skin, while consultant dermatologist Dr Alexandra Banner describes what’s happening in our bodies. Presenter: James Gallagher Producer: Hannah Robins

   August 18, 2026·28min
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   Number 2: Where are we at with long Covid?

   More than six years since the start of the Covid pandemic, it might feel like we're pretty over it, yet that's simply not the case for the millions of people who suffer from long Covid. But could there be hope on the horizon? A new clinical trial led by University College London and University College London Hospitals found that over-the-counter antihistamines and a prescription anti-inflammatory drug called colchicine offered a small reduction in fatigue for people with long Covid. But it's still not a cure. Professor Danny Altmann, an immunologist at Imperial College London, joins us to discuss this new research and the problems with understanding long Covid. He also tells us about some of the upcoming studies that might help us better get a handle on the condition. Also this week, did you know that around one in 335 people in the UK are living with a stoma? Yet according to Colostomy UK, more than 60 per cent of those with a stoma say a lack of suitable toilet facilities affects their daily lives. Thanks to a campaign that started in Bristol, B&Q has now made the disabled toilets across its stores stoma-friendly. We pay a visit to B&Q with The Traitors' Mollie Pearce, who has been living with a stoma since she was 18, and colorectal surgeon Ms Caroline Burt from Bristol Foundation Trust to find out more. Finally, many of us have been guzzling ice cream to cool off during the hot weather. But have you seen the social media claims that the frozen treat can reduce your risk of developing type 2 diabetes? We asked nutritional scientist Dr Sarah Berry from King's College London to give us the scoop on the 'ice cream paradox'. Presenter: James Gallagher Producer: Alice Lipscombe-Southwell Production coordinator: Stu Laws Editor: Ilan Goodman

   August 11, 2026·28min
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   Number 3: Staying fit in the heat and do we need electrolytes?

   We’ve had two heatwaves already this summer with warnings that even young and healthy people should rethink their fitness routines in the heat. So how can we keep exercising when it’s so hot you barely want to move? James chats with physiologist Damian Bailey from the University of South Wales. Next, James is at Rother Valley Country Park in Sheffield to meet Calli Hauger-Thackery who made headlines for running the Boston marathon while 22 weeks pregnant and physiotherapist Ros Cooke to find out what changes in the body during pregnancy - and see what exercise is safe. So we’ve worked up a sweat… but what’s the best way to recover? We’re in the lab at the University of Westminster to put electrolytes to the test with Dr Lewis Mattin and we cool off with Ros Cooke while chatting about active recovery versus total rest. Presenter: James Gallagher Special appearance: Hannah Fisher Producer: Gerry Holt Editor: Ilan Goodman Production coordinator: Stu Laws

   July 28, 2026·28min
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   Number 4: Could CAR-T therapy transform autoimmune disease?

   An experimental treatment to “reset” the immune systems of people with autoimmune disease is showing transformative results in early trials. James visits the NIHR Clinical Research Facility in Manchester to meet Kathy. She was diagnosed with lupus just after the birth of her baby and in 2024 became the first person in the UK to try CAR-T therapy as part of a clinical trial. How is she feeling now? We’ll also hear from Kathy’s rheumatologist Professor Ben Parker, who led the trial Kathy took part in and explains how the therapy works, the astonishing early results - and whether the effects on the immune system are long lasting. Also this week, James visits the London School of Hygiene and Tropical Medicine to meet some lab-grown British mosquitoes and find out whether they’re out to get us for longer periods of the year and how worried we should be about the threat of disease, with medical entomologist Dr Mojca Kristan and virologist Professor Roger Hewson. And we look at the latest online trend of “spermmaxxing” with urologist Professor Vaibhav Modgil. Why are men trying to optimise their sperm by dipping their testicles in iced water and abstaining from porn - and is there any evidence for these tactics? Presenter: James Gallagher Producer: Gerry Holt Editor: Ilan Goodman Production coordinator: Stu Laws Sound engineer: Mary Stone

   July 14, 2026·28min
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   Number 5: What are the side effects of weight loss drugs?

   Over 1.5million adults in the UK tried weight loss drugs in 2024-25. Many swear by them, but they have been associated with side effects including nausea and, in some cases, extremely painful gallstones. But what does the evidence actually tell us, and what is the wider impact on the way we view our bodies in society? James Gallagher is joined by Professor of Cardiometabolic Medicine at the University of Glasgow Naveed Sattar, Dr Beverley O’Hara, Lecturer in Public Health Nutrition at Leeds Beckett University, and Dr Margaret McCartney, resident Inside Health GP. They discuss what the evidence tells us about the potential known side effects of these weight loss drugs, and the potential impact their use has on our view of obesity as a society. We also hear from Sarah Le Brocq, who has struggled with obesity all her adult life and has been on these drugs for the past 2-3 years about her experiences. Margaret McCartney has no conflicts of interest to declare. Beverley O’Hara has no conflicts of interest to declare. She has 2 roles with the Association for the Study of Obesity (voluntary academic positions). Naveed Sattar has consulted for and/or received speaker honoraria from AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Carmot Therapeutics, Eli Lilly, Gan & Lee, GlaxoSmithKline, Hanmi Pharmaceuticals, Kailera, Mass Medicines, Menarini-Ricerche, Metsera, Novo Nordisk, Pfizer, Regeneron, Roche, UCB Pharma, and Verdiva Bio; and received grant support paid to his University from AstraZeneca, Boehringer Ingelheim, Novartis, and Roche. Presenter: James Gallagher Producer: Hannah Fisher Researcher: Tom Hunt Production coordinator: Stuart Laws Content Editor: Ilan Goodman

   February 24, 2026·29min
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