What happens when humanity faces the sixth mass extinction event in Earth's history? Serial entrepreneur Ben Lamm believes we need a backup plan. With a track record of building and exiting companies across AI, gaming, and conversational intelligence, Ben took on his most audacious venture in 2021: co-founding Colossal Biosciences with Harvard geneticist Dr. George Church to bring extinct species back to life. The company has already successfully de-extincted the dire wolf and aims to return woolly mammoths to the Arctic by 2028. In this episode, Ben shares how his self-described "unemployable" streak became his entrepreneurial superpower, why asking naive questions helps him tackle impossible challenges across industries, and how Colossal's breakthrough technologies represent humanity's essential insurance policy for planetary survival.

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With software powering every aspect of our lives, when does quality testing shift from a nicety to an absolute necessity? Despite the stakes, most companies fail to test everything—and even fewer automate their QA processes—leaving critical systems vulnerable to catastrophic bugs. Jon Perl is on a mission to change that. In 2019, he launched QA Wolf to help hundreds of companies automate 80% of their quality assurance processes, accelerating release cycles fivefold and saving customers over $100 million annually. By disrupting the outdated, manual QA status quo, QA Wolf empowers teams to ship faster and more confidently, delivering innovation without compromise. In this episode, Jon shares how a tech mistake sparked the idea for QA Wolf, how they settled on a pricing model that aligns incentives with their customers, and why he believes human-in-the-loop will remain essential until AI achieves flawless accuracy.

For 60 years, Moore's Law and Dennard scaling drove the exponential advancement of computers, making them faster, smaller, and more energy-efficient. But as Nick Harris explains, the era of transistor-based technology has reached its physical limits. The future of computing demands a new solution, and that solution is light. Nick founded Lightmatter in 2017 to fully transform AI data center infrastructure. By harnessing light to process and transmit data, Lightmatter is laying the foundation for the next generation of computing. The company invented the world's first 3D-stacked photonics engine and was most recently valued at $4.4 billion. In this episode, Nick shares why he chose to leave academia after receiving his PhD, how his go-to-market strategy hinged on building real friendships and understanding his customers' internal roadmaps, and why he believes that having an obsession is a gift.

What if building a website wasn’t just for developers, but something anyone could do easily? This was the simple idea that led Avishai Abrahami to create Wix in 2006. What began as a no-code tool to help businesses establish an online presence has grown into a global platform that serves hundreds of millions of users. Under Avishai’s leadership, the company has reached many milestones including the launch of Wix’s first AI website builder in 2016—one the first commercial AI products available to consumers at mass scale. In 2013, Avishai took Wix public, and the company is currently valued at over $11 billion. In this episode, Avishai shares his take on what differentiates exceptional entrepreneurs from the rest, why he believes in meticulously tracking the most granular details, and how important it is to master the balance of seeking feedback while knowing when to trust your own judgment.

What if the media you consume isn’t just how you spend your time—but who you become? Chris Best began his career as a software engineer, driven by the idea that writing code could transform how millions of people work. But after nearly a decade of coding, he recognized an even greater potential with writing: the power to shape who millions of people become. In 2017, Chris launched Substack, a platform that empowers independent writers and creators to own their connection with audiences and earn through paid subscriptions. In this episode, Chris unpacks the “anti-media” philosophy at the heart of Substack—eliminating barriers for writers to share their work and creating a meritocratic space where the most influential voices can be heard. From political commentators and fashion gurus to sports enthusiasts, Substack has grown into a vibrant ecosystem where readers can discover their tribe. Today, the platform boasts over 35 million active readers and more than 4 million paid subscribers. Chris shares how he overcame initial skepticism about product-market fit, why he thinks of Substack as an index for culture, and how authenticity is increasingly vital in a world where AI generated content is limitless.

Following the clean-tech bust of the early 2010s, the path to renewable energy was anything but clear. Yet in 2013, Chris Hopper took a bold step forward to co-found Aurora Solar, on a mission to accelerate solar energy adoption. Aurora’s platform streamlines and improves the processes of sales, design, and installation—making solar more accessible and efficient for all. Operating in a tough funding environment, he relied on grit to secure a seed round that enabled the company to bootstrap and grow steadily over the next five years. Today, Aurora Solar has raised over half a billion dollars, achieved a valuation exceeding $4 billion, and has empowered the design of over 10 million solar projects worldwide. Chris shares why he’s grateful for the challenging early days, how Aurora's cloud-based platform uses AI to streamline workflows, and why—despite his forward-thinking mindset—he encourages entrepreneurs to remain open to serendipity.

In 2011, as the rise of digital media cast doubt on the survival of print, Sarah Harrelson broke from convention and launched her own independent magazine: CULTURED. Sarah set out to spotlight artists, writers, curators, and designers overlooked by mainstream outlets and has since become one of the most trusted voices in the world of art and design. Beyond the magazine’s editorial prestige, CULTURED collaborates with leading fashion houses, luxury brands, and galleries. Sarah has had a decades-long career in magazines, beginning with an internship at Elle and including launching the Miami Herald’s Home and Design section, becoming the editor-in-chief of Ocean Drive and Art Basel Magazine, and ultimately founding her own publishing company. In this episode, Sarah shares how intuition shapes her approach to talent discovery, why her belief in the staying power of print remains unchanged, and how the magazine’s strategic focus has evolved to span global markets and adjacent industries.  

In 2013, when Ryan Petersen launched Flexport, he approached the problem from a customer’s perspective. Early in his career, he had worked at his brother’s import-export business, sourcing and selling ATVs, scooters, and dirt bikes from Asia to markets around the world. They built the entire technical platform to facilitate these transactions, and Ryan saw an opportunity to make the freight forwarding industry more efficient. He founded Flexport to make global trade easy and accessible for everyone and has since raised $2.3 billion to fuel the business. Today, Flexport’s platform coordinates logistics from factory floor to customer door, serving companies of all sizes. In 2023 alone, Flexport’s technology moved over $32 billion worth of merchandise. Ryan discusses how he leverages the U.S. Air Force’s OODA (Observe, Orient, Decide, Act) strategy, how AI is helping automate 1% of its freight forwarding workflows each week, and why Flexport’s agility remains the company’s greatest strength.

When Eliot Horowitz, Founder and CEO of Viam, was locked down with his family during COVID, he did what any engineer might do—he built a robot to play chess. Once that project was complete, he turned his attention to his ever-problematic sprinkler system. After that? He added smart software to his HVAC system. Through this series of home improvements, he uncovered a problem he was eager to solve, and his third startup was born. Eliot founded Viam to build a product that connects hardware to software and unlocks AI, automation, and data for the physical world. A career software developer and technology leader, Eliot previously co-founded MongoDB, writing the core code base for the pioneering database and leading the engineering teams for 13 years as CTO. MongoDB went public in 2017 and has a market cap of over $20 billion. Eliot shares why he enforces a no-jerk policy when it comes to hiring, how he evolved as a founder from the seed stage to post-IPO, and why he believes that being the product’s biggest user is essential to success.

In 2007, Emmett co-founded a live streaming service called Justin.tv along with his childhood friend and neighbor, Justin. That first entrepreneurial spark grew into Twitch, an interactive livestreaming service that spans gaming, entertainment, sports, music, and more. Today, at any given moment, more than 2.5 million people globally are engaging with Twitch. While Twitch was acquired by Amazon in 2014 for nearly $1 billion, Emmett has stayed on as CEO and continued to scale. Emmett shares why the company's hardest engineering challenge was scaling live video, why the future of the creator economy is "micro-patronage," and the role Twitch plays in combating loneliness. 

Original airdate: Aug 2022