Gestational age estimation is foundational for obstetric care. In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Author Jeffrey Stringer, MD, University of North Carolina, joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps. Related Content:

• Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps
• Enhancing Obstetric Ultrasonography With Artificial Intelligence in Resource-Limited Settings

Biomarkers for Alzheimer disease (AD) provide insight into disease processes and may aid clinical diagnosis for individuals with cognitive impairment. Author Stephen Salloway, MD, MS, of Brown University joins JAMA Deputy Editor Christopher Muth, MD, to discuss 2 articles and an accompanying editorial about blood biomarkers for AD and potential implications for clinical practice. Related Content:

• Are Blood Tests for Alzheimer Disease Ready for Prime Time?
• Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care
• Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia

Ulcerative colitis can significantly decrease quality of life. A third of patients have persistent symptoms with tumor necrosis factor inhibitors and nearly 1 in 5 patients will be hospitalized within 5 years of diagnosis. Author Gilaad G. Kaplan, MD, MPH, of the University of Calgary joins JAMA Associate Editor John M. Inadomi, MD, to discuss Risankizumab for Ulcerative Colitis. Related Content:

• Monoclonal Antibody Risankizumab for Ulcerative Colitis
• Risankizumab for Ulcerative Colitis

What are the ovarian cancer risks associated with endometriosis subtypes? Author Karen C. Schliep, PhD, MSPH, of the University of Utah joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Endometriosis Typology and Ovarian Cancer Risk. Related Content:

• Endometriosis Typology and Ovarian Cancer Risk
• New Insights in Endometriosis Subtypes and Ovarian Cancer Risk

Oral nicotine pouches are becoming more popular in the US, based on a survey performed in 2022. Hongying Daisy Dai, PhD, from Nebraska Medical Center, Omaha, discusses nicotine pouches and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content:

• Prevalence of Nicotine Pouch Use Among US Adults

Availability of pediatric care is decreasing, despite the growing complexity of pediatric care needs. Match rates for pediatric residency continue to decline. The US risks a serious shortage of pediatricians. Julie Byerley, MD, MPH, executive vice president & chief academic officer, Geisinger, Pennsylvania, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content:

• Where Are All the Pediatricians?

Facilitating safe and timely health care for individuals planning medication abortion is a reproductive health care priority. Lauren J. Ralph, PhD, MPH, and Daniel Grossman, MD, of University of California San Francisco join JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Comparison of Effectiveness of No-Test Telehealth and In-Person Medication Abortion. Related Content:

• Comparison of No-Test Telehealth and In-Person Medication Abortion

Can a new ECG finding identify individuals at risk for dying suddenly? Jason D. Roberts, MD, of McMaster University joins JAMA Associate Editor Gregory M. Marcus, MD, MAS, to discuss A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome (CRDS). CRDS is a recently described cause of sudden arrhythmic death. Until now, no clinical test has existed to identify those with the disease. Related Content:

• A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome
• The First Clinical Test for Calcium Release Deficiency Syndrome?

Joel M. Dulhunty, MD, PhD, Royal Brisbane and Women’s Hospital, and Jason A. Roberts, BPharm, PhD, University of Queensland Centre for Clinical Research, join JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the BLING trial that assessed continuous vs intermittent β-lactam antibiotic infusions in patients with sepsis or septic shock. Related Content:

• Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis
• Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock

Randomized clinical trials (RCTs) frequently fail to generate knowledge relevant to practice, while practice patterns are frequently unsupported by RCT evidence. Derek C. Angus, MD, MPH, of the University of Pittsburgh, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided. Related Content:

• The Integration of Clinical Trials With the Practice of Medicine