JAMA Clinical Reviews

Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration (FDA). Author G. Caleb Alexander, MD, MS, from Johns Hopkins discusses this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS. Related Content:

• The US Food and Drug Administration's Regulation of Mifepristone
• Politics, Science, and the Future of FDA Drug Regulation

Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide. JAMA Review author Haeseong Park, MD, MPH, from the Dana Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content:

• Gastric Cancer

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts in 2025. Related Content:

• Managing Adverse Effects of Obesity Medications
• Diagnosis and Management of Hypothyroidism
• Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment
• Managing Adverse Effects of Incretin-Based Medications for Obesity
• Hypothyroidism
• Diagnosis and Treatment of Type 2 Diabetes in Adults
• JAMA Editors' Choice 2024: Clinical Reviews Podcasts

In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup. Related Content:

• Research of the Year 2025

Obesity affects more than 1 billion people worldwide and is recognized by the World Health Organization as a chronic, relapsing disease. WHO recently published a guideline in JAMA on the use and indications of GLP-1 therapies for the treatment of #obesity in adults. Francesca Celletti, MD, PhD, and Ezekiel Emanuel, MD, PhD, join JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss. Related Content:

• World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults

Head and neck cancer is the seventh most common cancer worldwide and is commonly associated with tobacco and alcohol use, or human papillomavirus (HPV) infection. Author Lara Dunn, MD, of Memorial Sloan Kettering Cancer Center joins JAMA Associate Editor Margaret Wheeler, MD, to discuss the epidemiology, risk factors, diagnosis, treatment, and prognosis of head and neck cancer. Related Content:

• Head and Neck Cancer

Allergic rhinitis affects about 1 in 6 US adults. A recent JAMA Insights summarizes evidence regarding the associations of climate change and air pollution with allergic rhinitis and sinusitis. The discussion includes prevention and management strategies. Coauthor Neelima Tummala, MD, joins JAMA Deputy Editor Mary McDermott, MD, to discuss. Related Content:

• Climate Change, Allergic Rhinitis, and Sinusitis

Clinicians should weigh benefits against risks when engaging patients in informed discussions about cannabis or cannabinoid use. Kevin Hill, MD, MHS, of Harvard Medical School joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence about the therapeutic use of cannabis and cannabinoids in adults, potential harms, and evidence-based clinical guidance. Related Content:

• Therapeutic Use of Cannabis and Cannabinoids

Peripheral neuropathy affects approximately 1% of adults worldwide and can be associated with significant disability. Author Michelle Mauermann, MD, of the Mayo Clinic in Minnesota joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss diagnosis and optimal management of peripheral neuropathy. Related Content:

• Peripheral Neuropathy

Metabolic dysfunction-associated steatotic liver disease (MASLD), an increasingly prevalent condition among adults worldwide, is associated with liver-related complications, hepatocellular carcinoma, and certain extrahepatic cancers. Author Norbert Stefan, MD, from the University Hospital of Tübingen in Tübingen, Germany, discusses this and more with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content:

• Metabolic Dysfunction–Associated Steatotic Liver Disease in Adults

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JAMA Editors' Summary