JAMA Clinical Reviews

The GLP-1 receptor agonists reduce appetite and greatly facilitate weight loss. Robert Kushner, MD, of Northwestern University Feinberg School of Medicine joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss appropriate diet and exercise recommendations for patients receiving GLP-1 receptor agonists for weight loss. Related Content:

• Lifestyle Modification and Incretin-Based Therapy for Obesity
• The Conundrum of Exercise for Weight Management in the GLP-1 Receptor Agonist Era

Amyotrophic lateral sclerosis (ALS), which affects about 25 000 individuals in the US, causes progressive weakness but has varied presentations. Several FDA-approved medications are now available for ALS. Author John Ravits, MD, of UC San Diego School of Medicine joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss current evidence regarding diagnosis and treatment of ALS. Related Content:

• Amyotrophic Lateral Sclerosis
• Pridopidine in Amyotrophic Lateral Sclerosis
• What Is Amyotrophic Lateral Sclerosis?
• CNM-Au8 in Amyotrophic Lateral Sclerosis
• Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis
• Traumatic Brain Injury and Risk of Amyotrophic Lateral Sclerosis

Hepatitis B virus (HBV) infection affects around 254 million people worldwide and causes more than 1 million deaths annually. Author Anna Lok, MD, from the University of Michigan discusses HBV transmission, screening, and treatment with JAMA Associate Editor Beverly Forsyth, MD. Related Content:

• Hepatitis B
• Hepatitis B Virus Treatment Gaps in the US
• Tenofovir and Hepatitis B Virus Transmission During Pregnancy
• US Newborn Hepatitis B Virus Vaccination Rates

Heart failure (HF) affects more than 64 million individuals worldwide, and 20% to 30% of patients with HF and systolic dysfunction have cardiac dyssynchrony due to conduction system disease. JAMA Review author Mihail Chelu, MD, PhD, of Baylor College of Medicine discusses cardiac resynchronization therapy with JAMA Associate Editor David Simel, MD, MHS. Related Content:

• Cardiac Resynchronization Therapy
• Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

In the US, approximately 66% of reproductive-aged women have at least 1 modifiable risk factor for adverse pregnancy outcomes. Authors and ob-gyns Kylie Cooper, MD, and Daniel Breitkopf, MD, both from the Mayo Clinic, discuss ways to reduce maternal morbidity and mortality and improve neonatal outcomes with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content:

• Prepregnancy Care and Counseling

Endometrial cancer accounts for 95% of uterine cancers, which are the fourth most common cancer in women in the US. Author Karen McLean, MD, PhD, of Roswell Park Comprehensive Cancer Center joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence about diagnosis and treatment of endometrial cancer. Related Content:

• Endometrial Cancer

Explore evidence-based clinical signs, diagnostic accuracy, and practical assessment strategies to optimize care with an in-depth look at the latest information on pediatric concussion. JAMA Review author Sonal N. Shah, MD, MPH, of Boston Children's Hospital, discusses this and more with JAMA Associate Editor David Simel, MD, MHS. Related Content:

• Does This Child Have a Concussion?
• Even Mild Concussions Tied to Worse Cognition Later in Life
• Vestibular/Ocular Motor Screening (VOMS) in Suspected Concussion
• Balance and Gait Assessment Including Modified BESS
• Cervical Spine Examination in Suspected Concussion

Absolute iron deficiency with or without anemia affects about 2 billion people worldwide and 14% of adults in the US. Discover causes, diagnosis, and best practices for oral and intravenous iron therapy in adults in this discussion between Michael Auerbach, MD, from Georgetown University School of Medicine, and JAMA Associate Editor Margaret Wheeler, MD. Related Content:

• Iron Deficiency in Adults

Interview with Thomas Ibounig, MD, author of Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging and Brian T. Feeley, MD, author of Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes. Hosted by Eve Rittenberg, MD. Related Content:

• Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging
• Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes

Resistant hypertension affects about 10% of those treated for hypertension. Managing it involves lowering sodium intake, exercising, losing weight, reducing alcohol consumption, and using optimal diuretics, combination pills, and mineralocorticoid antagonists. Author Michel Azizi, MD, PhD, from Hospital European Georges Pompidou in France discusses this and more with JAMA Associate Editor David L. Simel, MD, MHS. Related Content:

• Diagnosis and Management of Resistant Hypertension