India’s tech ecosystem has hit an indisputable inflection point in recent years. For decades, American corporations outsourced basic services to India, while India outsourced its top talent to Silicon Valley. But today, India’s tech economy boasts homegrown software giants and a flourishing startup scene.

This week, we get a front-row look into India’s startup evolution with one of its top talents: Sri Ganesan, Founder and CEO of Rocketlane. His first company, Konotor, was acquired into Freshworks, which went public in 2021 for $10 billion and became one of India's biggest wins. Now, Sri is building Rocketlane into a leading solution for SaaS deployment and professional services automation, with teams in the U.S. and India. By combining American know-how with Indian talent, Rocketlane represents an important dynamic for the future of tech and expanding key partnerships around the world. 

In this episode, we dive into the lessons learned from Freshworks's success and how it paved the way for greater entrepreneurial risk within India. We also explore Sri's journey in scaling Rocketlane, from finding product-market fit to positioning the company to take advantage of the AI wave. We discuss what India’s rise to become one of the world's most important economies means for the future of tech and global talent distribution, along with the cultural differences between India and the US, and what it's like building on two continents simultaneously. Finally, Sri guides us through the various tech hubs in India, from Mumbai to Bangalore and Chennai, even down to his favorite restaurant and must-visit destinations for anyone heading to India soon.

Every year, more than 20,000 Americans receive a bone marrow transplant — a Nobel prize-winning procedure that saves many lives but also carries great risk. For leukemia patients, it's a choice of last resort, as nearly 20% die from the transplant. Ivan Dimov, co-founder & CEO of Orca Bio, and his team have created a novel cell therapy alternative that has already saved over 400 lives in clinical trials with virtually zero rejection!This week, we dive into Ivan's journey, the science behind Orca's cancer breakthrough, and the potential of cell therapies to cure a host of other diseases.  By discovering new, high-precision methods to manipulate cells, Orca is able to provide leukemia patients with a designer immune system that attacks the cancer while nearly eliminating rejection. By safely rebooting the immune system, Ivan and his team believe Orca also has the potential to cure autoimmune diseases like Crohn’s disease and multiple sclerosis, and impact the lives of millions of Americans.Orca is currently seeking the first-ever FDA approval in this space, and since it's a unique one-time curative therapy, they are also commercializing the drug in-house — a rare move in biopharma. Ivan walks us through the path to bringing Orca's products to market, from collaborating with regulators to negotiating with insurance companies and scaling up its manufacturing. Though many challenges remain, you'll see why we're incredibly bullish on Ivan's leadership and Orca's potential to transform the future of medicine.

What are the forces behind the scenes that drive financial markets? How do bubbles form — and are we in one now? What do the world's best investors understand and how do they consistently come out ahead? 

This week we dive into global finance with one of the sharpest minds in macro investing: Whitney Baker, Founder and Chief Investment Officer of Totem Macro. Whitney previously worked at two of the world's leading investment firms, first in global macro & long/short strategies at Soros Fund Management and most recently as the Head of Emerging Markets at Bridgewater Associates. 

In this episode, Whitney lays out the principles behind macro investing and how credit flows, borrowing cycles, and monetary policy drive global finance. She traces our current-day situation back to the 1970s when President Nixon ditched the gold standard and opened trade with China. She explains how a new age of deficit spending combined with China entering the U.S. bond market paved the way for the dot com bubble, and ultimately where we are today. Whitney makes the case that inflation isn't going away soon and believes the Federal Reserve's actions over the past few decades have exacerbated inequality in America. Yet, despite these headwinds, Whitney believes technological progress can sustain the U.S. through these challenging times, so long as we set the right conditions for our best entrepreneurs to succeed. 

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U.S. e-commerce sales eclipsed $1 trillion last year and are expected to double or triple over the next decade. As online demand increases, how can small businesses compete with retail giants like Amazon and Walmart? What capabilities do they need? And can a new model help level the playing field? 

This week, we explore the future of logistics and e-commerce with Tyler Scriven, co-founder and CEO of Saltbox. Tyler was a star talent at Palantir for many years (his first job title was "Predictor and Crusher" on account of his ability to eliminate operational challenges) before applying his learnings to help entrepreneurs nationwide. He identified a key gap in the market: small businesses have great software tools, but need help in the physical world with supply chain and logistics to compete against large retailers with scale advantages. With a dozen locations in major metropolitan areas, Saltbox provides a unique co-warehousing model to elevate storage and shipping capabilities. 

In this episode, we discuss Tyler's most important lessons from Palantir and how to cultivate a mission-driven culture. We cover his entrepreneurial journey from Palantir to acquiring his own small business and discovering the logistical shortcomings that Saltbox is designed to solve. We also talk leadership lessons and Tyler's compelling perspective on "courage for normal people." 

Leonard Leo is one of the most effective agents of legal and cultural change in America today. What's his playbook?  How can we apply it to other broken areas of society?  And why should the technology world be especially interested in his work?

In the mid-20th century, the U.S. judicial system took a sharp left turn, resulting in hyper-politicized courts, runaway bureaucracies, and many other distortions of our Constitutional system. Through his leadership of the Federalist Society, Leonard has led the charge to repair these broken institutions and, in the process, built arguably the most powerful legal network in the nation. He's been instrumental in the most important judicial elections and nominations of the past few decades. 

Leonard's wisdom is especially relevant for my friends in the effective accelerationism (e/acc) movement — or anyone who values technological progress.  Standing athwart innovation is the ever-expanding administrative state, and Leonard has spent decades fighting to rightsize government and restore the separation of powers. He explains why property rights, limited government, and decentralized power are the bulwark of innovation, and why technologists must also join the effort to rein in the regulatory state and defend these sacred Constitutional principles. 

What are the single most effective policies for helping the world's poor? And what are we doing right now that's ineffective and should be stopped? The answers may surprise you. 

In his latest book "Best Things First," Bjorn Lomborg reveals the 12 best solutions to address the most pressing global challenges. He gathered the world's top economists to analyze the policies that would do the most good for the least amount of money. It turns out the United Nations and others are getting it wrong — climate policies didn't make Bjorn's list! 

In 2015, the UN released its Sustainable Development Goals — a mere 169 promises to achieve by 2030! Yet as Bjorn explains, these are largely virtue signaling or ineffective vows the UN will never make good on. Instead of overpromising or obsessing over climate change, Bjorn says the evidence points to 12 clear and measurable policy solutions: eliminating tuberculosis, investing in education the right way, and establishing clear land rights, to name a few. 

Bjorn is the Founder and Director of the Copenhagen Consensus think tank and one of the world's most influential writers and thinkers. He's made a career challenging misguided narratives, especially on environmental issues, while fighting to restore sanity and fact-based policymaking. His arguments are a direct challenge to the alarmism and doomerism surrounding us today, which is why YouTube and others try to censor him! 

By the summer of 2012, ride-sharing had arrived: Uber launched its everyman product, UberX, and Lyft debuted hot on its heels. Today, Lyft's market cap hovers around $5 billion while Uber's is north of $140 billion. How did Uber explode to global dominance? What was different about its culture? And how did it take on taxi cartels around the world and win? 

This week, we go behind the scenes with Emil Michael, one of Silicon Valley's great operators and dealmakers. As the former Chief Business Officer, Emil helped Uber raise a record $15 billion in two years and led its expansion into the most difficult markets, including China, Russia, Saudi Arabia, and Italy. (Yes, Italy.)  Emil recounts his biggest wins and toughest challenges, including how the Italian mafia threatened to kill Uber employees and why to this day ride-sharing is almost nonexistent in Italy. 

Emil immigrated with his family to the U.S. from Egypt as a young child, and his success and character epitomize the American Dream. He graduated from Harvard, received his J.D. from Stanford Law, and began his entrepreneurial journey at TellMe, an early speech recognition company.  He quickly became known for his dealmaking skills, including transforming a $300 million acquisition offer into a $800 million deal with Steve Ballmer and Microsoft. After TellMe, he served as a White House fellow at the Pentagon and spent time in Iraq and Afghanistan, before later joining Uber. We dive into his unique approach to high-stakes negotiations and lessons learned from his distinguished career. 

Can investigative journalism prevail over sensational clickbait? Is it time to give up on San Francisco? Is the First Amendment sufficient to prevent the government from colluding with, or forcing, Big Tech to censor speech? This week, join us for a one-of-a-kind conversation with Mike Solana, Chief Marketing Officer at Founders Fund and Founder of Pirate Wires, one of the fastest-growing and most influential new media companies. Mike is a must-follow on X for his wit and unique insights, but also for the work he's doing to expose corruption and revive investigative reporting. Pirate Wires recently revealed how San Francisco taxpayers are being forced to fund the protests that shut down the Bay Bridge! We begin our discussion with the broken state of media, and why Mike believes a subscription model is the path to building a successful media outlet that isn't beholden to clickbait. Next, we discuss whether SF can be saved from the far Left and why we need better elites who don't blindly fund radical non-profits. We also cover several of Mike's seminal pieces of writing: the future of free speech when the government and Big Tech create a decentralized censorship regime, and how to revive our country's ability to build great, inspiring works. Can we restore competence in government or should we turn our energy and attention elsewhere? We discuss!

What is e/acc (effective accelerationism) and why is it going viral among tech's elite? Who are the leaders behind this movement and what are their ambitions? 

This week, we explore e/acc with one of its pioneers, Guillaume Verdon (aka @BasedBeffJezos), a theoretical physicist at the cutting edge of quantum computing and AI.  Guillaume worked under Sergey Brin as the quantum deep learning lead at Google X before launching a thermal computing startup called Extropic.  He started e/acc as a cultural counterforce to the degrowth and doomer movements that sow distrust of technology and seek to undermine the advancement of artificial intelligence and other emerging innovations. 

Fifty years ago, sci-fi was some of the most inspiring art in America.  It's no coincidence that it preceded the birth of the space and digital ages — the stories and narratives we tell ourselves as a society are the ones we tend to work toward.  Not surprisingly, as sci-fi took a dystopian turn in recent decades, society's view of technology and progress soured as well.  E/acc is the antidote; it aims to inspire a cultural, then technological, renaissance in the West.  While e/acc has gained popularity through viral memes on social media, it's also a cohesive framework designed to apply to the modern world.  In this episode, we discuss the first principles behind e/acc, steelman the arguments against it, and explore how it's compatible with religion and other ethical frameworks.  This is an important movement that resonates with us at American Optimist. 

Who should be in charge of the culture of a company? How do you maintain a spirit of innovation as an organization scales? How can executives be transparent about their shortcomings while also improving as leaders?

Scott Cook, the founder and former CEO of Intuit, has navigated these challenges himself while mentoring hundreds of other leaders on how to do the same. Scott is a legend of Silicon Valley. In 1983, he founded Intuit and pioneered consumer finance software, first with Quicken and later TurboTax, Quickbooks, and other products that quickly became household names.

During the 8VC Leadership Summit, I sat down with Scott to discuss some of his most important lessons learned and advice to CEOs and founders. He begins with the responsibility of the CEO to set the company culture, and why leadership doesn't get to play by a different set of rules than its employees. He also explains how success can make organizations slow and stupid, and how to fight the forces of inertia. One way is by orienting decision-making around experimentation, not opinion or status, and he illustrates how Intuit learned to adopt this mindset. Finally, he advises CEOs to advertise their failures, not bury them, and seek out accountability and outside scrutiny from coaches and advisors.