Joint Action

The first line pain relieving medication recommended in most therapeutic guidelines for osteoarthritis is the anti-inflammatory group of medications. They consistently demonstrate modest effects for relieving pain and improving function, pretty much irrespective of the site of osteoarthritis whether that be the hand, knee or hip. There is a huge variety of anti-inflammatories available, different routes of administration including oral and topical, different dosage strengths along with other elements that influence patient preference.

On this episode we discuss: what are non-steroidal anti-inflammatory drugs (NSAIDs) and how do they work, what are the side effects of taking NSAIDs and how often do these occur, how efficacious are NSAIDs for pain relief and much more

Prof Ric Day AM (MBBS, FRACP, MD) is internationally and nationally recognised for his research, leadership and advocacy in support of quality use of medicines (QUM). He has been deeply involved in Australia’s National Medicines Policy and the quality use of medicines component culminating in his Chairmanship of the Pharmaceutical Health and Rational Use of Medicines Committee (PHARM) for the Federal Government in 1999-2008. His research focuses on quality use of medicines and methods of enhancing the safe use of medicines using eHealth systems and decision support tools He has published over 600 peer reviewed papers. His current collaborations have lead to significant work investigating the potential of eHealth tools to increase medication safety but he has other significant areas of research. Prof Day is a committed undergraduate & post-graduate teacher & research mentor. Prof Day has received many awards, including Member of the Order of Australia AM.

RESOURCES

• NPS Medicinewise
• Arthritis Australia
• This Way Up

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

Hosted on Acast. See acast.com/privacy for more information.

Osteoarthritis is an extraordinarily prevalent and disabling disease. The prevalence appears to be increasing, in large part compounded by the ageing of the population but also with major contributions from demographic shifts as it relates to obesity are leading to increasing numbers of people with osteoarthritis. The two biggest risk factors for knee osteoarthritis are obesity and overweight and joint injury. They account for approximately 75% of a person’s likelihood of developing osteoarthritis of the knee. Both are eminently modifiable but from a public health perspective, we do very little if anything about modifying either.

On this episode we discuss: risk factors for developing osteoarthritis, how much weight to lose to reduce their risk of developing osteoarthritis, the effects of weight loss on osteoarthritis and much more.

Dr Jos Runhaar is an Assistant Professor at the Department of General Practice of Erasmus MC. Netherlands

He was trained as Human Movement Scientist at the Vrije University Amsterdam. For his PhD, he performed the first ever trial on the primary prevention of osteoarthritis, supervised by Prof. Bierma-Zeinstra and Prof. Koes. The research direction of Dr. Runhaar aims to improve the diagnosis and treatment of musculoskeletal disorders by general practitioners and physiotherapists and to shift the treatment of musculoskeletal disorders to the early disease phase.

RESOURCES

Journal articles

• What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies
• Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis
• To what extent is severe osteoarthritis preventable? Occupational and non-occupational risk factors for knee and hip osteoarthritis
• Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females
• Long-term effects of a randomized, controlled, tailor-made weight-loss intervention in primary care on the health and lifestyle of overweight and obese women
• Predicting Knee Pain and Knee Osteoarthritis Among Overweight Women

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review! :)

Hosted on Acast. See acast.com/privacy for more information.

Current management approaches for osteoarthritis are usually targeted to symptoms. One way to mitigate the epidemic of osteoarthritis is to modify both its structural progression and symptomatic consequences in tandem a method known as disease modification, as distinct from symptom modification. These could potentially slow the speed of disease progression, completely halted or in an ideal world reverse the disease and regenerate the target tissue. At present, despite a number of positive trials there are no drugs that have garnered regulatory approval for this indication.

On this week's episode we discuss: what is disease modification, what have the clinical trials shown, what will the future of DMOADs look like and much more.

Christoph Ladel is working as Translational Medicine Expert. Most recent position was as team lead in the global clinical development department in Merck Healthcare KGaA (Darmstadt, Germany). In his role he was involved in design and execution of clinical studies from phase 1 to phase 3. Special responsibility was in the field of biomarker and imaging (MRI and x-ray) read-outs in clinical studies, mainly in osteoarthritis. He contributed to the respective teams to analyze data and to develop further stratification strategies based on biomarkers (incl. imaging) for studies in osteoarthritis.

Christoph trained as an immunologist with a PhD in immunopharmacology and immunotoxicology Dr Ladel has worked in different companies and different countries. Over the >15 years he was part of project teams or team leader in different projects for the discovery and development of therapies in osteoarthritis. Christoph is an internationally recognized scientist and has authored > 50 scientific peer reviewed publications and is co-inventor in more than 10 patents in the field of clinical strategies for osteoarthritis.

RESOURCES

• David's presentation on DMOADS for the Arthritis Web Seminar Series at UHN
• Wikipedia page on DMOADS

Journal articles

• Current status and future prospects for disease modification in osteoarthritis
• Intra-articular therapies for osteoarthritis
• Emerging drugs for the treatment of osteoarthritis

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

Hosted on Acast. See acast.com/privacy for more information.

The economic burden due to osteoarthritis (OA) is massive and is the result of direct costs to the health care system, indirect costs to individuals living with OA, and the intangible costs of living with a chronic disabling condition. Compared to age and sex-matched peers, OA patients incur higher out of pocket health-related expenditures. People with OA also incur substantial costs due to lost productivity, including both absenteeism (days off work) and presenteeism (reduced self-reported productivity at work). As the burden of OA rises globally, so too will the economic burden

On this episode we discuss: the basic principles of osteoarthritis economics, average direct healthcare costs of living with osteoarthritis, total healthcare costs to the economy and much more.

Professor Elena Losina, Robert W. Lovett Professor of Orthopedic Surgery (Biostatistics) at Harvard Medical School, is an internationally recognized investigator in the epidemiology and outcomes of musculoskeletal disorders. She is a Director of the Policy and Innovation eValuation in Orthopedic Treatments (PIVOT) Center and co-Director of the Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) and is a Principal Investigator of the Methodology Core of the Robert Brigham Multidisciplinary Clinical Research Center at Brigham and Women’s Hospital, Boston, MA. Dr. Losina has published over 300 peer-reviewed articles. Dr. Losina leads an NIH funded multi-sited project to conduct health policy evaluations related to surgical and non-surgical management of knee osteoarthritis. She is recognized internationally for her expertise in melding rigorous clinical research methodologies across multiple clinical disciplines, from orthopedics and osteoarthritis to global health.

RESOURCES

• The Centre for Disease Control and Prevention - Osteoarthritis
• The Arthritis Foundation
• Arthritis Australia

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

Hosted on Acast. See acast.com/privacy for more information.

Hand osteoarthritis is a common musculoskeletal disease and associated with hand pain, stiffness, functional limitation and quality of life. For a long time, hand osteoarthritis was a "forgotten disease", resulting in a paucity of good quality clinical trials to help guide the management. However, in more recent years, hand osteoarthritis has gained more attraction and new data to support treatments has become available.

On this episode we discuss:

• what is hand osteoarthritis and which joints are most commonly affected
• why does hand osteoarthritis occur
• recommended treatments for hand osteoarthritis

Professor Margreet Kloppenburg is heading the Osteoarthritis Research Group of the Rheumatology Department of the Leiden University Medical Center, Leiden, the Netherlands. She started research in the field of Osteoarthritis in the department of Rheumatology and made it one of its key research areas. The work of her group focusses on the causal role of systemic factors in osteoarthritis and on methodology to evaluate the course of osteoarthritis by MRI and radiographs, with special attention for hand osteoarthritis. Professor Kloppenburg has published over 200 peer-reviewed papers in the national and international literature.

RESOURCES

Journal articles

• EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis
• Efficacy and safety of non-pharmacological, pharmacological and surgical treatment for hand osteoarthritis: a systematic literature review informing the 2018 update of the EULAR recommendations for the management of hand osteoarthritis
• 2018 update of the EULAR recommendations for the management of hand osteoarthritis
• 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

YouTube video

• Hand exercises for hand osteoarthritis

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

This episode was produced in partnership with The Arthritis Foundation.

Hosted on Acast. See acast.com/privacy for more information.

Foot osteoarthritis affects one in six adults over the age of 50. It is associated with restricted mobility, disability, poor balance, risk of falling and accounts for a substantial number of healthcare consultations. Due to this, there is an increasing interest in research into foot osteoarthritis and we are learning more about foot osteoarthritis and it's prevalence, risk factors and treatments for this condition. Listen to this episode of Joint Action to learn more about foot osteoarthritis with Professor Hylton Menz.

On this episode we discuss:

• the prevalence of foot osteoarthritis
• how foot osteoarthritis is diagnosed
• current research into foot osteoarthritis
• appropriate treatment for foot osteoarthritis (including footwear)

Professor Hylton Menz is a podiatrist who graduated with first class Honours and the University Medal from La Trobe University in 1993, and completed his PhD focusing on gait patterns, balance and falls at the University of NSW in 2002. He is currently a National Health and Medical Research Council of Australia Fellow. Professor Menz's broad research disciplines are human movement, rehabilitation and rheumatology, with a particular focus on musculoskeletal foot problems in older people. His research extends from laboratory-based biomechanical studies through to analysis of epidemiological datasets and the conduct of clinical trials. Professor Menz has published over 300 papers in podiatry, gerontology, rheumatology and biomechanics journals. Professor Menz's current research focuses on the epidemiology and management of foot disorders in older people, with a particular emphasis on osteoarthritis.

RESOURCES

• Australian Podiatry Association webpage
• College of Podiatry UK webpage
• Arthritis Australia webpage

CONNECT WITH HYLTON

• Twitter
• Webpage

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

Hosted on Acast. See acast.com/privacy for more information.

On this special episode of Joint Action, we have the privilege of hearing from Tom Buttel and his journey with osteoarthritis. Hear Tom's story and learn how he manages his osteoarthritis to continue living an active lifestyle. We hope that by sharing Tom's story, we are able to motivate and stimulate change in others.

On this episode we discuss:

• the development of Tom's osteoarthritis
• management/strategies to control the symptoms of osteoarthritis
• perspectives of different health care providers and the management of osteoarthritis
• and much more!

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

Hosted on Acast. See acast.com/privacy for more information.

Approximately 20% of people who go on to develop osteoarthritis do so a result of an injury sustained earlier in their life. The anterior cruciate ligament or ACL, is the most common anatomical structure that accounts for a large proportion of the risk of developing osteoarthritis. Tune into this episode to learn more about ACL injuries and what we can do to reduce joint injury.

On this episode we discuss:

• factors which predict an ACL injury
• neuromuscular factors which put a person at risk for injuring their ACL and how are these neuromuscular imbalances identified
• neuromuscular training programs
• how to reduce re-injury after an ACL injury
• the risk of developing osteoarthritis following an ACL injury

Timothy E. Hewett Ph.D. is former Director of The Biomechanics Laboratories and Sports Medicine Research Center at Mayo Clinic and Director of the Sports Health & Performance Institute at The Ohio State University and Professor and Director of Sports Medicine Research at OSU and Professor and Director of the Sports Medicine Biodynamics Center at Cincinnati Children's Hospital and Research Foundation. He was a Professor in Sports Medicine, Family Medicine, Orthopaedic Surgery, Physiology and Cell Biology and Biomedical Engineering and Allied Health Professions at The OSU, Pediatrics and Orthopaedic Surgery at the University of Cincinnati College of Medicine. Dr. Hewett possesses a doctorate in Physiology and Biophysics and a postdoctoral fellowships in Molecular Biology & Biomechanics, Pharmacology and Cell Biophysics and Human Biomechanics. Over four hundred of his research articles have appeared in peer-reviewed medical journals, with over 50,000 citations of his work in the medical literature.

RESOURCES

Journal articles

• National Athletic Trainers' Association Position Statement: Prevention of Anterior Cruciate Ligament Injury
• Risk of Secondary Injury in Younger Athletes After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis
• Understanding and preventing acl injuries: current biomechanical and epidemiologic considerations - update 2010
• Preventive Neuromuscular Training for Young Female Athletes: Comparison of Coach and Athlete Compliance Rates
• Compliance with neuromuscular training and anterior cruciate ligament injury risk reduction in female athletes: a meta-analysis
• Effects of compliance on trunk and hip integrative neuromuscular training on hip abductor strength in female athletes
• Current concepts for injury prevention in athletes after anterior cruciate ligament reconstruction
• What is the Evidence for and Validity of Return-to-Sport Testing after Anterior Cruciate Ligament Reconstruction Surgery? A Systematic Review and Meta-Analysis
• Return-to-sport testing following ACL reconstruction revisited

YouTube video

• Evidence based approaches to the reduction of primary and secondary ACL injuries

CONNECT WITH TIM

• Tim's YouTube Channel
• Twitter: @TimothyHewett1, @Hewett1Tim, @TimHewett5

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Email: [email protected]
• Website: www.jointaction.info/podcast

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!

Hosted on Acast. See acast.com/privacy for more information.

Dr. Leigh Callahan is the Director of the Osteoarthritis Action Alliance (OAAA). She is also an epidemiologist and outcomes researcher who, for more than 30 years, has worked in musculoskeletal outcomes research.

Her research has focused on predictors of outcomes and quality of life in individuals with osteoarthritis (OA) and rheumatoid arthritis (RA), patient-reported outcomes and measurement, physical activity and arthritis, social determinants and health outcomes, health literacy, and complementary and alternative medicine use in rheumatic diseases.

She is also Professor of Medicine and Associate Director of the Thurston Arthritis Research Center, as well as Director of the UNC Core Center of Clinical Research that is focused on enhancing the design and conduct of clinical studies in rheumatic and musculoskeletal diseases.

On this episode we discuss: the work of the Osteoarthritis Action Alliance (OAAA), and their future directions

Resources:

• The OAAA webpage

Hosted on Acast. See acast.com/privacy for more information.

Dr. Zhang is the Director of Epidemiological and Biostatistical Methods in Rheumatology at Mass General and a Professor in Residence in Medicine at Harvard Medical School. He is a senior epidemiologist with expertise in study design and statistical analysis, and has mentored both MD and PhD trainees and junior faculty for over 30 years.

On this episode we discuss: racial differences in the prevalence of osteoarthritis, risk factors for certain populations and much more

Resources

• National Institute of Arthritis and Musculoskeletal and Skin Diseases
• Arthritis Foundation

Register for the Mine the Gap workshop here.

Hosted on Acast. See acast.com/privacy for more information.