Executive Editor Michael Roy speaks with Roscoe O. Brady, Jr., M.D., Ph.D., and Mark A. Halko, Ph.D., about their research on identifying and treating a network of connectivity in the brain corresponding to negative symptom severity in schizophrenia.  The difference between positive and negative symptoms in psychosis, and why the symptoms are important [2:39] Identifying the treating the underlying circuitry of negative symptoms in the brain [6:25] Discussion of the results of the study [10:20] Symptom severity and the link between the prefrontal cortex and cerebellum [12:27] Aspects of the study that are relevant for researchers, clinicians, and other mental health professionals [20:40] What's next in this line of research and clinical care [25:40]  Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Stitcher, or wherever you listen to it. The podcast is now on Spotify. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Also visit the online edition of this month’s Journal to watch a video of Deputy Editor Daniel S. Pine, M.D., present highlights from the issue. Follow the Journal on Twitter. E-mail us at ajp@psych.org

July 2019: Treating Negative Symptoms in Schizophrenia

Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.

This podcast is subject to the Terms of Use at ww.psychiatry.org.  The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent the views of the American  Psychiatric Association, its officers, trustees, or members. The content of this podcast is provided for general informational purposes only and is not intended as, and shall not be understood or construed as, medical or any other type of professional advice nor does it represent any statement of the standard of care. We strongly recommend that any listener follow the advice of physicians directly involved in their care and contact their local emergency response number for any medical emergency. The information within this podcast is provided as-is and is not guaranteed to be correct, complete, or accurate.

Medicine

Science & Medicine

Science

Health & Fitness

Dr. ReJoyce Green (Medical University of South Carolina, Charleston, SC) joins AJP Audio to discuss predictors of substance use initiation in a large cohort of early adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin speaks with AJP Deputy Editor Dr. Kathleen Brady about the May issue of AJP, a special issue guest edited by Dr. Brady focusing on latest developments in the understanding and treatment of substance use disorders. Transcript   00:48     Green interview  03:04     Why is it important to study substance use initiation?  04:06     Social and family-related factors versus imaging and neurocognitive factors  05:58     Age and cohort concerns  07:15     Religious participation as a predictive factor  09:04     Clinical implications  11:03     Limitations  12:24     What’s next for your research?  13:36     Kalin and Brady interview  17:09     Green et al.  19:52     Morley et al.  23:34     Radoman et al.  26:21     Hoffman et al.  29:00     Blalock et al.  Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.  Subscribe to the podcast here.  Listen to other podcasts produced by the American Psychiatric Association.  Browse articles online.  How authors may submit their work.  Follow the journals of APA Publishing on Twitter.  E-mail us at ajp@psych.org

May 2024: Predictors of Substance Use Initiation by Early Adolescence

Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin in youths with severe irritability.  00:56     Hwang interview 02:09     Effects of oxytocin 05:45     Intranasal oxytocin 07:04     Potential adverse effects of oxytocin 08:08     Imaging 08:58     Preliminary investigations and clinical implications 09:51     Limitations 10:14     Further research 11:00     Kalin interview 11:33     Hwang et al. 14:43     Leibenluft et al. 15:39     Aggarwal et al. 18:22     Pezzoli et al. 21:34     Kendler et al. 23:30     Hou et al.   Transcript  Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.  Subscribe to the podcast here.  Listen to other podcasts produced by the American Psychiatric Association.  Browse articles online.  How authors may submit their work.  Follow the journals of APA Publishing on Twitter.  E-mail us at ajp@psych.org

April 2024: Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability

Dr. Drew Rothenberg (Duke University, Durham, NC) joins AJP Audio to discuss the long term, intergenerational impacts of the Fast Track program, and whether the mental health intervention lead to lasting improvements in mental health, including in the participants own children.     00:49     Rothenberg interview  04:36     A null result?  07:13     At risk children from high risk neighborhoods  08:00     Limitations  09:17     Demand for childhood mental health services and clinical implications  11:10     Further research  13:59     Kalin interview  14:12     Rothenberg et al.  16:12     Haller et al.  18:49     Poirot et al.  20:55     Ainsworth et al.  23:20     Rosenqvist et al.   Transcript  Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.  Subscribe to the podcast here.  Listen to other podcasts produced by the American Psychiatric Association.  Browse articles online.  How authors may submit their work.  Follow the journals of APA Publishing on Twitter.  E-mail us at ajp@psych.org

March 2024: Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial

Dr. Ofir Livne (Columbia University, New York) joins AJP Audio to discuss recent trends in the prevalence of cannabis use disorder in US veterans with and without psychiatric disorder diagnosis.  Dr. Ned Kalin joins afterwards to discuss how the rest of the February issue of AJP touches on cannabis use disorder and other substance use disorders.   00:31     Livne interview  03:16     Changes in the legal landscape surrounding cannabis use  05:17     The complex association between cannabis use and psychiatric disorders  07:20     Clinical implications  08:02     Limitations  09:44     Future directions for research  10:13     Kalin interview  10:30     Livne et al.  12:30     Gustafson et al.  14:44     Garland et al.  16:10     Wilson et al.  18:06     Huang et al.   Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.  Subscribe to the podcast here.  Listen to other podcasts produced by the American Psychiatric Association.  Browse articles online.  How authors may submit their work.  Follow the journals of APA Publishing on Twitter.  E-mail us at ajp@psych.org

February 2024: Trends in Prevalence of Cannabis Use Disorder Among U.S. Veterans With and Without Psychiatric Disorders Between 2005 and 2019

 Dr. Jaclyn Ross, Ms. Jordan Barone, and Dr. Tory Eisenlohr-Moul (University of Illinois at  Chicago) join AJP Audio to discuss the impact of the menstrual cycle on suicide ideation and planning in psychiatric patients with suicidality.  Afterwards,  American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin brings us up to date on the rest of the January issue of AJP.   Transcript  Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.  Subscribe to the podcast here.   Listen to other podcasts produced by the American Psychiatric Association.  Browse articles online.   How authors may submit their work.  Follow the journals of APA Publishing on Twitter.  E-mail us at ajp@psych.org

January 2024: Predicting Acute Changes in Suicidal Ideation and Planning: A Longitudinal Study of Symptom Mediators and the Role of the Menstrual Cycle in Female Psychiatric Outpatients With Suicidali

July 2019: Treating Negative Symptoms in Schizophrenia

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