Kelsey Grammer is best known for his two-decade-long portrayal of psychiatrist Dr Frasier Crane which began on the NBC sitcom Cheers. He continued the role in the hugely successful spin-off series Frasier which ran for 11 years. When the series ended in 2004, it had won a total of 35 Emmys.

Born in the Virgin Islands, he was brought up by his mother and maternal grandparents in Florida, after his parents divorced. He studied drama at the Julliard School in New York but left before the end of the second year. He got his big break when he joined the cast of Cheers in 1984.

In his personal life Grammer has experienced a great deal of loss - his much-loved grandfather died when he was 12 and his 18 year old sister was murdered when he was 20. His struggles with drink and drugs, now behind him, are well documented. Married four times, he is the father of seven.

The winner of multiple awards, he is also a TV producer, director, writer, and known for his voice work: among others he was Sideshow Bob in The Simpsons and Stinky Pete in Toy Story 2. He is currently on stage in London.

Presenter Kirsty Young