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Latest Advances in Tumor-Agnostic Strategies for NTRK Fusion-Positive Cancer
Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain, practicing community oncologists, share their key takeaways from a session on NTRK Fusion Positive Solid Malignancies, they moderated during a satellite event at ASCO 2025 in partnership with Medscape Global Oncology.
Join us as we discuss:
• The prevalence of NTRK fusions in various cancers and why community oncologists should be aware of them.
• The importance of comprehensive next-generation sequencing (NGS) for detecting these fusions across diverse histologies.
• Available treatment options, including first-generation NTRK inhibitors like larotrectinib and entrectinib, and their efficacy in improving overall and progression-free survival.
• Insights into the CNS activity of these treatments and the common side effects patients may experience.
• Special considerations for pediatric patients, including formulation challenges and the potential for re-challenging with NTRK inhibitors.
Don't forget to check out the full accredited enduring program by Medscape Global Oncology linked below, and earn your CME credit.
https://www.medscape.org/viewarticle/1002679?src=acdmpart_onc-brothers_1002679
Follow us on social media:
• X/Twitter: https://twitter.com/oncbrothers
• Instagram: https://www.instagram.com/oncbrothers
• Website: https://oncbrothers.com/
#entrectinib #larotrectinib #repotrectinib
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By Oncology Brothers
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3939 ratings
Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain, practicing community oncologists, share their key takeaways from a session on NTRK Fusion Positive Solid Malignancies, they moderated during a satellite event at ASCO 2025 in partnership with Medscape Global Oncology.
Join us as we discuss:
• The prevalence of NTRK fusions in various cancers and why community oncologists should be aware of them.
• The importance of comprehensive next-generation sequencing (NGS) for detecting these fusions across diverse histologies.
• Available treatment options, including first-generation NTRK inhibitors like larotrectinib and entrectinib, and their efficacy in improving overall and progression-free survival.
• Insights into the CNS activity of these treatments and the common side effects patients may experience.
• Special considerations for pediatric patients, including formulation challenges and the potential for re-challenging with NTRK inhibitors.
Don't forget to check out the full accredited enduring program by Medscape Global Oncology linked below, and earn your CME credit.
https://www.medscape.org/viewarticle/1002679?src=acdmpart_onc-brothers_1002679
Follow us on social media:
• X/Twitter: https://twitter.com/oncbrothers
• Instagram: https://www.instagram.com/oncbrothers
• Website: https://oncbrothers.com/
#entrectinib #larotrectinib #repotrectinib
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