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In this “Lessons” episode, Stanford neuroscientist David Eagleman shares how challenging the brain with novelty—like learning unfamiliar skills—builds new neural pathways that can delay dementia more effectively than diet or supplements. He explains why mental and social engagement, not comfort or routine, protects long-term brain health, citing studies showing how cognitively active people maintain sharpness despite physical signs of degeneration. Eagleman also introduces the idea of “Ulysses contracts”—clever psychological tricks to help us resist short-term temptations by making decisions in advance when we’re thinking clearly.

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