Marc Maron’s podcast WTF recently ended its run, so today Asif and Ali discuss Maron and his influence on comedy and podcasting (6:18) (after a brief digression on a fundraiser Ali recently went to). They begin by discussing Maron’s early life and career. They discuss him getting involved in radio and all the acting roles he has done in the past 20 years. They then discuss Maron’s recent stand up special “Panicked”. Finally they discuss WTF, the importance of the show for comedy and podcasting in general and the most memorable episodes. 

In Marc Maron’s recent special he discusses SSRI’s (for his cats!)‚ so in the second half, they discuss these drugs (31:31). Asif talks about selective serotonin reuptake inhibitors, how they work and what they are used for. He then goes over the common types of SSRI’s as well as their potential side effects. Asif then discusses how sometimes people can have a difficult time coming off SSRI’s. Finally Ali asks Asif about other things that can be used for depression such as natural products and exercise. 

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Music courtesy of Wataboi and 8er41 from Pixabay

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Show Notes:

Marc Maron’s Rawest Interview Yet. The Truth About Grief, Anger, and Connection: https://www.menshealth.com/entertainment/a65608892/marc-maron-wtf-podcast-legacy-interview/

Selective Serotonin Reuptake Inhibitors: https://www.ncbi.nlm.nih.gov/books/NBK554406/

Many People Taking Antidepressants Discover They Cannot Quit: https://www.nytimes.com/2018/04/07/health/antidepressants-withdrawal-prozac-cymbalta.html?rref=collection%2Fsectioncollection%2Fhealth&action=click&contentCollection=health®ion=rank&module=package&version=highlights&contentPlacement=6&pgtype=sectionfront

Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses: https://pubmed.ncbi.nlm.nih.gov/27113121/

Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regressio: https://bjsm.bmj.com/content/57/16/1049?trk=article-ssr-frontend-pulse_x-social-details_comments-action_comment-text

Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials: https://www.bmj.com/content/384/bmj-2023-075847.abstract

Great Depresh’ Comedian Gary Gulman Has 5 Tips to Get Through Isolation: https://www.hollywoodreporter.com/tv/tv-news/big-depresh-comedian-gary-gulman-coping-isolation-1285949/

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