Dr Mark Mattson is now retired, but was a professor of Neuroscience at Johns Hopkins University. He’s one of the foremost researchers in the area of cellular and molecular mechanisms underlying neurodegenerative disorders such as Alzheimer’s and Parkinson’s. Previously, he was chief of the Laboratory of Neurosciences at the National Institute on Aging Intramural Research Program (IRP) at the National Institutes of Health since 2000. 

Dr Mattson spent his career investigating cognitive function and tools used to help delay the progression of cognitive decline.

Mark's research was the catalyst for the now popular 5:2 diet protocol, and since then there has been a raft of TRE protocols used to help improve metabolic health, allergies, respiratory problems, cognitive decline and cancer treatment.

Mikki and Mark talk about what autophagy means (and what triggers it), what we know from rodent trials as to the efficacy of fasting for humans, what breaks a fast and the therapeutic use of fasting for cancer treatment.

Effects of fasting on health, ageing and disease https://www.nejm.org/doi/full/10.1056/NEJMra1905136

Alternate Day Calorie Restriction Improves Clinical Findings and Reduces Markers of Oxidative Stress and Inflammation in Overweight Adults with Moderate Asthma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859864/

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women https://pubmed.ncbi.nlm.nih.gov/20921964/

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