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Mikki dives into the complex and controversial topic of sucralose—one of the most common non-nutritive sweeteners—and whether it interferes with hunger and satiety signalling in the brain. Prompted by a new study published in Nature, Mikki explores how sucralose might increase activity in brain regions associated with hunger and reward, particularly in women and individuals with obesity or insulin resistance. She unpacks the mechanisms at play, discusses the relevance of acute vs long-term data, and weighs these findings against the broader scientific literature on artificial sweeteners. If you've ever wondered whether your sweet tooth could be tricking your brain, this episode is for you.
Highlights:
https://www.nature.com/articles/s42255-025-01227-8
https://pmc.ncbi.nlm.nih.gov/articles/PMC7817779/#s4
https://pubmed.ncbi.nlm.nih.gov/39015535/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7155288/
Contact Mikki:
https://mikkiwilliden.com/
https://www.facebook.com/mikkiwillidennutrition
https://www.instagram.com/mikkiwilliden/
https://linktr.ee/mikkiwilliden
Save 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.com
Curranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
5
1414 ratings
Mikki dives into the complex and controversial topic of sucralose—one of the most common non-nutritive sweeteners—and whether it interferes with hunger and satiety signalling in the brain. Prompted by a new study published in Nature, Mikki explores how sucralose might increase activity in brain regions associated with hunger and reward, particularly in women and individuals with obesity or insulin resistance. She unpacks the mechanisms at play, discusses the relevance of acute vs long-term data, and weighs these findings against the broader scientific literature on artificial sweeteners. If you've ever wondered whether your sweet tooth could be tricking your brain, this episode is for you.
Highlights:
https://www.nature.com/articles/s42255-025-01227-8
https://pmc.ncbi.nlm.nih.gov/articles/PMC7817779/#s4
https://pubmed.ncbi.nlm.nih.gov/39015535/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7155288/
Contact Mikki:
https://mikkiwilliden.com/
https://www.facebook.com/mikkiwillidennutrition
https://www.instagram.com/mikkiwilliden/
https://linktr.ee/mikkiwilliden
Save 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.com
Curranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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