The Dr Louise Newson Podcast

178 - My story of ‘treatment resistant depression’, ketamine and HRT


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In this episode, Sam shares her moving account of the journey she has been on for the last five years when, after a miscarriage and losing her father, things started to unravel and her mental health suffered. A difficult few years followed spent navigating depression, trialling several antidepressants and anti-anxiety medications, and seeking help from psychiatrists to try and understand what was going on. At the time, Sam believed she was years away from becoming menopausal and through her own research sought treatment privately in the form of ketamine due to her desperation to feel better and function again. Through learning more about hormones and their effects on the brain and mental health, Sam has recently begun to take HRT and feels she has started on a more positive path to health and stability.

Sam’s three tips for those struggling with mental health:

  1. Try and be assessed by a menopause specialist before accepting a diagnosis, medication or treatment from a psychiatrist – it may save you a lot of unnecessary suffering.
  • If you do start taking HRT, be patient. It can take time and the dose and type may need tweaking before you feel the beneficial effects.
  • Become as well informed as you can about your hormones and the menopause from good sources online. And talk to other women – you’re not alone.
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    The Dr Louise Newson PodcastBy Dr Louise Newson

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