In this episode of SurgOnc Today, live from SSO 2024, Dr. Alex Parikh from the University of Texas – San Antonio and Chair of the SSO HPB disease site working group, and Dr. Julie Hallet from the University of Toronto, and Vice-Chair of the SSO HPB disease site working group, are joined by Dr. Ana Gleisner from the University of Colorado and Dr. Skye Mayo from the Oregon Health and Sciences University. They will be discussing two important aspects of the surgical management of perihilar cholangiocarcinoma: determining resectability as it relates to vascular involvement, and the role of neoadjuvant therapy.