Is an Omicron infection inevitable? Which drugs still work? Is this the last hurrah of the pandemic? This week we have three of the country’s greatest scientific minds teasing apart what Omicron means for our lives now and in the future. Prof Eleanor Riley, Prof Azra Ghani and Prof Sir Martin Landray also tackle your, at times controversial questions! And our regular Dr Rohin Francis gives us a first-hand account of the pressures on NHS staff?