Let's talk about oral estrogen, which is a form of hormone replacement therapy many doctors still recommend—even though sometimes perhaps they shouldn't. In addition to that, many women use synthetic oral estrogens, like birth control pills, for decades.

The more information you have regarding your choices for estrogen replacement, the better decision you can make for yourself. Whatever form you choose, it should be able to enter your body, circulate, reach the proper receptors, and be eliminated effectively. Essentially, it needs to be bioavailable and activate receptors on the target cells to achieve desired results.

Oral estrogens have minimal systemic bioavailability—between 2% and 10%. This is due to the first pass effect and demonstrates how a huge amount of this dose does not make it into the circulatory system. Despite this, they are still often prescribed by doctors who are making recommendations based on outdated or biased information.

There is no established ideal hormone level at menopause, which can make it more difficult for women on hormone replacement therapy to figure out their most effective dose. It really comes down to weighing the benefits being experienced against the potential side effects or risks. Often, these risks are there regardless due to age, so many women feel the positive effects are worth it.

Synthetic hormone use comes with its share of things to consider. To keep this in perspective, we have to remember that many women are exposed to synthetic hormones via birth control measures. That means we have to account for this too when looking at the data. If you're taking or considering taking oral estrogen, it's best to understand the upsides along with the dangers that could be lurking.

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