In this episode Lewis First, MD, MS, FAAP, editor-in-chief of Pediatrics, is back for another edition of “First Up.” He joins hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, with a bird’s-eye view of what’s in the May issue of the journal. The hosts also talk to David Kimberlin, MD, FAAP, editor of the Red Book about what to expect in the 2021 edition released this month.