Literature Review Series

October 2023

Special Guests: Hailey Burns, PharmD @Hailey_rx36

Caitlyn Simonson, PharmD

03:45 – Featured Articles

38:15 – Neuro

50:10 – EM/Tox/Trauma

61:50 – Renal/Endocrine

66:38 – PharmD

70:10 – Sweet Emotion

Reference List: https://pharmacytodose.files.wordpress.com/2024/03/october-lrs-2023-references.pdf

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Sweet 16 Preview and Recap: 2024 Critical Care Trials March Madness Bracket Preview

04:06 – First round recap

13:25 – Second round recap

19:05 – Sweet 16 preview

PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf

2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/

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Pharmacotherapy in the Critically Ill Pregnant Patient: Part II

Special Guests: Allison Lankford, MD

Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin

04:50 – Obstetric hemorrhage

18:20 – Ectopic pregnancy

22:30 – Hypertensive emergency

28:45 – Pre-eclampsia/eclampsia

35:00 – Lactation considerations

39:35 – Take-home points

Pharmacotherapy “Caring for two in the ICU” articles:

Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/

Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/

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2024 Critical Care Trials March Madness Bracket Preview: Part II

Cardiac/Pulmonary and Sepsis/Fluids Regions

CV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCP

Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCP

PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf

2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/

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2024 Critical Care Trials March Madness Bracket Preview: Part I

Bleeding/Blood Glucose and Neuro/PADIS Regions

Bleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCM

Neuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP @karenccrx

PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf

2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/

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Trial of the Week: CHAMPION PHOENIX

Special Guest: Jack Pluenneke, PharmD, BCCP @JackPluenneke

Jack Pluenneke joins to discuss a March 2024 Trial of the Week, “Effect of platelet inhibition with cangrelor during PCI on ischemic events” the CHAMPION PHOENIX trial, published in 2013 in NEJM. 

We review PK/PD advantages with cangrelor, go over the CHAMPION trials, and then highlight why the CHAMPION PHOENIX trial was necessary. Then we dive into the Trial of the Week: CHAMPION PHOENIX trial and discuss its findings as well as study design. Are these patients we’d see in our ICU? How does cangrelor compare to glycoprotein 2b/3a inhibitors? Is it a weakness that the comparator group uses clopidogrel? The episode closes with medication safety considerations, cangrelor’s place in therapy, and much more.

Reference list:  https://pharmacytodose.files.wordpress.com/2024/03/champion-phoenix-trial-of-the-week-references-1.pdf

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Corticosteroids in the Critically Ill

Special Guest: Andrea Nei, PharmD, BCPS, BCCCP, FCCM @Dre_pharmd

04:40 – Guideline introduction/background

08:35 – Scope/authorship

13:35 – PICO questions/recommendations

14:22 – Sepsis

17:20 – CAP

19:10 – ARDS

21:55 – Research priorities/Take-home points

28:50 – Working with your spouse

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Trial of the Week: REDUCE

Special Guest: Matt Duprey, PharmD, PhD, BCCCP

Matt Duprey joins to discuss the March Trial of the Week, published in 2018 in JAMA: “The Effect of Haloperidol on Survival Among Critically Ill Adults with a High Risk of Delirium: the REDUCE Randomized Clinical Trial.”

We review the history of antipsychotic pharmacotherapy treatment and prophylaxis in delirium, reviewing guideline recommendations from that time. Then we dive into the Trial of the Week: REDUCE trial and discuss its findings as well as study design. Would results be the same with another medication? Why is delirium research so challenging? Prevalent v. incident delirium? What’s the best outcome to measure? What questions still need answered? These questions and so much more are answered in today's episode.

Reference list:  https://pharmacytodose.files.wordpress.com/2024/03/reduce-references.pdf

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Pharmacotherapy in the Critically Ill Pregnant Patient: Part I

Special Guests: Allison Lankford, MD

Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin

08:05 – PK/PD changes

12:50 – Medication safety/Drug information resources

20:15 – Maternal sepsis

33:15 – ARDS

43:15 – PADIS

48:45 – Cardiogenic shock & cardiac arrest

59:00 – VTE

Pharmacotherapy “Caring for two in the ICU” articles:

Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/

Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/

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Trial of the Week: Levetiracetam Rapid IV Push

Special Guest: Olivia Morgan, PharmD, BCCCP, BCGP

I’m joined by Olivia Morgan to discuss her first author 2020 Neurocritical Care article entitled “Safety and Tolerability of Rapid Administration Undiluted Levetiracetam.”

We review previous administration techniques and discussing how this study came to be before highlighting all the findings from this Trial of the Week. Then we discuss how the protocol has changed since this study, administering other ASM via rapid IV push, and much, much more.

Reference list:  https://pharmacytodose.files.wordpress.com/2024/03/keppra-rapid-ivp-references.pdf

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