It's a crossover conversation between The Hilarious World of Depression's John Moe and Ana Marie Cox, host of the podcast "With Friends Like These." Both shows traffic in the idea of having more conversations about things that don't get talked about very often. In that spirit, John and Ana Marie open about some events that drive them and that they have never discussed much in public. If you need immediate help, confidential help is available for free in the U.S. at the National Suicide Prevention Lifeline, 1-800-273-TALK.