Here is a summary of this episode:

• In patients with liver impairment, it is better to use drugs that are metabolized by phase II enzymes or drugs that are not metabolized by the liver at all.
• Patients with severe renal impairment may also have liver impairment. Use ⅔ of the recommended dose.
• Benzodiazepines and Z-drugs are contraindicated in CO2 retainers and those with severe sleep apnea. Opiates are better than benzodiazepines in patients with terminal breathlessness.

• Download a PDF of this interview here
• Learn more about our memberships here