Through no fault of their own, ADHD medications often bear the misconception of being ineffective — or worse, unsafe — yet they are the first line of treatment used by many physicians, including primary care pediatricians. Katrina A. Fletcher, MD, attending psychiatrist in the Department of Child and Adolescent Psychiatry and Behavioral Sciences at Children's Hospital of Philadelphia, provides a broad overview of ADHD medications, including the highs and lows of varying treatments, from increased productivity to loss of appetite; the trial and error in determining the correct dosing; adjuncts such as behavioral interventions; and more.