Inflammation, recurrent infections, fevers and rashes, and poor growth may all be ways that immune dysregulation presents in primary care patients. Edward Behrens, MD, Chief of the Division of Rheumatology at Children's Hospital of Philadelphia, discusses the Dysregulated Immune Response Team (DIRT) and their innovative approach to immune dysregulation management. Using a multidisciplinary team, precision medicine, collaborative research, and care coordination, the DIRT program is improving care for patients with rare diseases.