The new SMART guidelines for children whose asthma is not well controlled, including use of one inhaler for maintenance and rescue, was a significant change to which both caregivers and providers are still adjusting. Tyra Bryant-Stephens, MD, Medical Director of the Community Asthma Prevention Program and Chief Health Equity Officer of the Center for Health Equity at Children's Hospital of Philadelphia, reviews: who is eligible for SMART; signs and symptoms of asthma that is not well controlled; case examples; tips for discussing the changes with parents; tips for SMART prescription-writing; benefits of the new guidelines; and more.