In this episode of the PFC Podcast, Dennis and Kevin dive deep into the complexities of ketamine, exploring its pharmacodynamics, pharmacokinetics, and practical applications in emergency medicine. They discuss the drug's disassociative properties, its analgesic effects, and the importance of individualized dosing based on patient physiology. The conversation also touches on the risks of catecholamine depletion and the management of side effects, particularly in trauma patients. Throughout the discussion, Kevin shares valuable insights and practical advice for medics and healthcare professionals using ketamine in real-life scenarios.

Takeaways

Ketamine is an NMDA receptor antagonist with various effects on the body.

It can cause profound analgesia and disassociation at different doses.

S-ketamine is preferred for its more intense analgesic effects and quicker recovery.

Dosing should be individualized based on patient condition and physiology.

Ketamine can lead to catecholamine depletion, especially in trauma patients.

Smaller doses are safer for patients with compromised vital signs.

Analgesic effects can be achieved without full disassociation at lower doses.

Managing side effects is crucial, especially in the 'party zone' of ketamine use.

Always have a plan for potential complications when using ketamine.

Refer to clinical practice guidelines (CPGs) for best practices.

Chapters

00:00 Understanding Ketamine: Basics and Mechanisms

09:17 Pharmacokinetics of Ketamine: How It Works

15:58 Dosing Ketamine: Individualized Approaches

25:23 Analgesic Properties of Ketamine: Beyond Disassociation

31:39 Managing Side Effects: The Party Zone and Hallucinations

39:19 Catecholamine Depletion: Risks and Considerations

43:05 Practical Advice for Medics: Using Ketamine Safely

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