In this promethazine pharmacology podcast, I discuss its mechanisms of action, side effects, important drug interactions, and much more.

Promethazine has anticholinergic and dopamine-blocking activity which contributes to the adverse effect profile as well as its efficacy.

There is a boxed warning with promethazine to avoid the use of this medication in patients under the age of 2 due to respiratory depression.

Promethazine IV is considered a high-risk route of administration and should be avoided if possible.

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