In this episode, we discuss the causes of clozapine-induced orthostasis. Although some patients may develop tolerance, it can limit titration and potentially obstruct patients from reaching the plasma level where they respond well to the medication. There are practical management strategies for orthostasis, including slow titration based on patient complaints and encouraging fluid intake, among others.

Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D.

• Learn more about our memberships here
• Earn 1.25 CME: Managing Some Unique Nonhematologic Adverse Effects of Clozapine
• Managing Clozapine-Related Orthostasis

In this episode, we discuss the potential of lavender extract, Silexan, as an alternative treatment for anxiety and insomnia with Dr. Jim Phelps. Is it truly a promising solution free from dependency and withdrawal symptoms or just an effective placebo?

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 48
• Effect of Anxiolytic Drug Silexan on Sleep – A Narrative Review

In this episode, we explore a common yet severe side effect of clozapine: Constipation. Why does this drug cause such drastic changes in colonic transit times, and how can we manage it effectively?

Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D.

• Learn more about our memberships here
• Earn 1.25 CME: Managing Some Unique Nonhematologic Adverse Effects of Clozapine
• Managing Clozapine-Related Constipation

In this episode, we discuss a comprehensive study on the potential cardiovascular risks of ADHD medication. Although these medications pose minimal risk for those without preexisting conditions, there seems to be an elevated risk for those with preexisting cardiovascular diseases. Should we confidently prescribe these medications?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: CAP Smart Takes Vol. 09
• Risk of Cardiovascular Diseases Associated With Medications Used in ADHD

In this episode, we delve into the problem of sialorrhea or excessive salivation in patients on clozapine. Why does this occur, and how can it be managed? Join us as Dr. Jonathan Meyer shares his expertise on this unique side effect.

Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D.

• Learn more about our memberships here
• Earn 1.25 CME: Managing Some Unique Nonhematologic Adverse Effects of Clozapine
• Managing Clozapine-Related Sialorrhea

Can a simple lab test guide our choice of antidepressants? Explore the intriguing link between inflammation, measured by C-reactive protein (CRP) levels, and the effectiveness of certain antidepressants in this episode.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 48
• C-Reactive Protein Could Predict the Efficacy of SSRIs in Clinical Practice: A Cohort Study of Large Samples in the Real World

Could ketamine be the breakthrough we need in treating adolescent depression? Join us in this episode as we explore the potential of ketamine therapy and its rapid antidepressant effects. Also, learn how ketamine works, its safety profile, and why it's not quite ready for mainstream use in adolescents.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: CAP Smart Takes Vol. 08
• Ketamine for Adolescent Depression

In this episode, we dive into the puzzling case of a 67-year-old man experiencing violent moving nightmares. Is it rapid eye movement sleep behavior disorder, frequent and recurring nightmares, night terrors, PTSD, or another parasomnia? Tune in as we explore potential diagnoses with our expert Dr. Carlos Schenck.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

• Learn more about our memberships here
• Earn 0.75 CME: Parasomnias Triggered by Antidepressant Medications: REM SleepBehavior Disorder and Restless Legs Syndrome
• A Clinical Case and Exclusive Videos On RBD and RLS

In this episode, we delve into a new horizon in the management of acute agitation. We discuss dexmedetomidine, a drug that's been around since 1999, recently reformulated into a sublingual film and FDA approved for treating agitation associated with schizophrenia or bipolar I or II disorder. We explore the results from a recent randomized trial and its potential for transforming psychiatric care. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

• Learn more about our membership here
• Earn 0.5 CMEs: Quick Take Vol. 47
• Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial

In this episode, we dive into rapid eye movement sleep behavior disorder (RBD). Did you know that RBD's prevalence is on par with schizophrenia in middle-aged and older adults? Tune in as we explore the prevalence, assessment, and management of RBD, a condition that is not only a sleep disorder but a potential harbinger of severe neurological conditions, like Parkinson's Disease and Dementia with Lewy Bodies.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

• Learn more about our memberships here
• Earn 0.75 CME: Parasomnias Triggered by Antidepressant Medications: REM Sleep Behavior Disorder and Restless Legs Syndrome
• Prevalence, Assessment, and Management of RBD