In this episode, the editorial team of the Psychopharmacology Institute discusses 3 important topics presented at the APA Annual Meeting: Prescribing psychiatric medications during pregnancy, recent advances in clozapine treatment, and managing eating disorders, namely anorexia nervosa and bulimia nervosa. The episode covers the safety and dose adjustments for medications like SSRIs, lamotrigine, and lithium during pregnancy; early initiation and monitoring of clozapine; and effective treatments, including psychotherapy, olanzapine, and fluoxetine for eating disorders.

Hosts: Flavio Guzman, M.D., Paz Badia, M.D., and Lorena Rodriguez, M.D.

In this episode, we discuss a new study on maternal depression, antidepressant use, and pregnancy complications. Can antidepressants during pregnancy harm the baby? Dr. Lauren Osborne helps us weigh the risks and benefits.

Faculty: Lauren Osborne, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 56
• Neonatal and Pregnancy Complications Following Maternal Depression or Antidepressant Exposure

In this episode, we explore the most effective pharmacologic treatments for fibromyalgia, a complex nociplastic pain syndrome. Dr. Daniel Clauw shares his insights on the top drug classes for managing fibromyalgia and discusses why opioids should be avoided. Could the hyperactive endogenous opioid system in fibromyalgia patients explain the ineffectiveness of opioids?

Faculty: Daniel Claw, M.D. Host: Richard Seeber, M.D.

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• Earn 0.75 CME: Nociplastic Pain Syndromes: Focus on Fibromyalgia
• Pharmacologic Therapies for Fibromyalgia

In this episode, we explore the use of antipsychotic medication in treating children and adolescents with anorexia nervosa. Can these medications play a role in promoting weight gain and reducing comorbid symptoms? Or do the risks outweigh the potential benefits in this vulnerable population?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: CAP Smart Takes Vol. 15
• Antipsychotics in the Treatment of Youth With Anorexia Nervosa

In this episode, we dive into the diagnosis of fibromyalgia, a common nociplastic pain syndrome. We explore how to assess widespread pain and associated symptoms and how to understand fibromyalgia as a spectrum rather than a binary diagnosis. How can this nuanced approach help us tailor treatment strategies? 

Faculty: Daniel Clauw, M.D. Host: Richard Seeber, M.D.

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• Earn 0.75 CME: Nociplastic Pain Syndromes: Focus on Fibromyalgia
• Diagnosing Fibromyalgia

In this episode, we delve into the potential for irreversible sexual dysfunction after SSRI use, based on a large-scale Israeli study. Could a few months or even days of antidepressant treatment lead to permanent erectile issues?

Faculty: Paul Zarkowski, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 55
• Risk of Irreversible Post‑SSRI Sexual Dysfunction With Antidepressants

In this episode, we discuss the management of common adverse effects associated with clozapine treatment, including myocarditis, cardiomyopathy, tachycardia, orthostatic hypotension, and metabolic syndrome. How can clinicians mitigate these risks while optimizing treatment outcomes for patients with treatment-resistant schizophrenia? Faculty: Brian Miller, M.D. Host: Richard Seeber, M.D.

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• Earn 1.25 CME: Clozapine: Management and Challenges
• Managing Cardiac and Metabolic Adverse Effects of Clozapine

In this episode, we explore relapse prevention strategies for youth with depression and anxiety disorders. Are there effective ways to reduce the risk and prolong the time to relapse? Dr. David Rosenberg discusses the findings of a recent meta-analysis and systematic review on this crucial topic.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: CAP Smart Takes Vol. 15
• Relapse Prevention Strategies for Depression and Anxiety in Remitted Youth

In this episode, we navigate the complexities of initiating and optimizing clozapine treatment for patients with treatment-resistant schizophrenia. How do you chart the course for successful clozapine therapy while managing side effects and drug interactions? Join us as Dr. Brian Miller shares his expertise and valuable psychopharmacology pearls.

Faculty: Brian Miller, M.D. Host: Richard Seeber, M.D.

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• Earn 1.25 CMEs: Clozapine: Management and Challenges
• Initiating and Optimizing Clozapine

In this episode, we discuss the prevalence of smoking among people with psychosis, based on recent findings from the PATH study. Dr. Oliver Freudenreich shares insights on how clinicians can prioritize smoking cessation in this population. How can we bridge the health outcome disparities faced by our patients with psychosis?

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.

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• Earn 0.75 CMEs: Quick Take Vol. 55
• Tobacco Use, Nicotine Dependence, and Cessation Among Adults with Psychosis