Here is a summary of this episode:

• Always ask about over-the-counter drugs like antacids, antiemetics, and spasmolytics as they may interfere with drug absorption.
• In patients who have undergone gastric bypass, use immediate release formulations, or give liquid form of drugs.
• There is evidence to suggest that IBS-constipation responds better to SSRIs and IBS-diarrhea to TCAs.
• The risk of GIT bleeding with SSRIs is 1.5 to 2 times greater. Patients with a defect in platelet number or function and those who H. pylori infection are at greater risk.

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