This episode features a comprehensive Q&A session about the Sinclair Method (TSM) for addressing alcohol use disorder (AUD), hosted by Katie and Bruce, two experienced coaches working with individuals using this approach. The discussion centers on the unique, science-based mechanism of TSM, which uses the medication naltrexone (referred to as “nrexone” or “NTR”) to reduce alcohol cravings by targeting the brain’s endorphin addiction, rather than enforcing total abstinence. Bruce and Katie explain how alcohol triggers the release of endorphins—a natural brain chemical that produces pleasure and numbing effects—and how this neurochemical dependency fuels addiction. Unlike traditional abstinence-based treatments, which often fail due to intense cravings caused by removing alcohol (and thus endorphins) entirely, TSM allows controlled drinking while taking naltrexone to gradually “extinguish” the craving by breaking the endorphin-reward cycle.

They emphasize that TSM is a compassionate, forgiving, and flexible method that allows users to “press pause” during challenging life events, rather than forcing abstinence and self-denial. Naltrexone is taken about an hour before drinking to blunt the endorphin release, reducing the rewarding effects of alcohol and enabling gradual reduction or controlled drinking over time. The conversation also covers the importance of support structures, mindset work, counseling, and habit change alongside medication use. They discuss practical topics such as planning alcohol-free days, managing dosage timing, and differentiating between neurological addiction and psychological habit or emotional reliance on alcohol.

Bruce and Katie highlight that TSM success rates are around 78-80% when users are compliant with the medication protocol, and the program’s strength lies in combining neuroscience with behavioral change and emotional support. The dialogue also addresses common questions about supplements, the role of genetics in endorphin response, and how natural endorphin-producing activities (like exercise and social connection) can support recovery. The hosts encourage a kind, patient approach to recovery that includes self-compassion and realistic expectations, acknowledging that progress is gradual and nonlinear.

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/