About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

Dr. Volpicelli answers some questions for us. 

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

Q&A with Katie and Bruce 

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

Join me and guest Samara Boss, TSM Success Story and coach as we discuss life after AUD through TSM. Ready to get started or get supported on TSM?

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

Q&A with Katie & Bruce

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

In this episode, Dr. Joseph Vachelli, a leading expert on naltrexone (Nxone), discusses how patients can determine if they need a higher dose of the medication when treating alcohol use disorder. He explains that the standard dose of 50 mg may not be effective for everyone, especially those who continue to experience the pleasurable effects of alcohol despite taking the medication. Dr. Vachelli highlights that the effectiveness of naltrexone can be assessed by the change in how alcohol feels—specifically, a reduced “high” or euphoria and diminished cravings after a few drinks are signs that the dose is working. However, if someone still experiences a “buzz” or pleasurable effects from drinking, it may indicate that a higher dose is necessary or that the person metabolizes the drug quickly, reducing its efficacy.

He emphasizes that different drinking habits, such as rapidly consuming high-concentration alcohol like shots, may require a higher naltrexone dose compared to slower consumption of beer. Dr. Vachelli also clarifies that naltrexone does not block all effects of alcohol, particularly its sedative effects, so feeling tired after drinking is not an indication of insufficient medication.

Importantly, Dr. Vachelli warns against misusing naltrexone to “game” the system—to continue drinking and still achieve a buzz. He stresses the need for using naltrexone as part of a structured recovery plan that includes psychosocial and behavioral support. Drawing from his clinical experience, he shares that medication alone is insufficient if patients are not genuinely motivated to recover. He developed a psychosocial program to enhance treatment adherence and motivation, which dramatically improved outcomes.

Finally, he underscores the critical role of social support, such as peer groups or coaching, in sustaining recovery. Whether patients use the Sinclair Method, daily oral dosing, or extended-release injections, coupling medication with behavioral support is essential for long-term success in overcoming alcohol addiction.

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

In this episode it centers around a coaching call with a Thrive member who had been using the Sinclair Method (TSM) for three years but struggled to see meaningful progress. The individual was a daily drinker for 40 years prior to starting TSM and had been compliant with taking naltrexone (referred to as “nrex Zone” or “elrex Zone” in the transcript), yet did not experience alcohol-free days or significant change in their drinking habits. Eventually, they stopped the treatment but later restarted with a new mindset that led to better results. The core message is that success with the Sinclair Method requires more than just medication compliance; a fundamental mindset shift and intentional lifestyle changes are crucial. Specifically, having regular alcohol-free days and building new coping strategies and pleasures outside of alcohol play a vital role in achieving “extinction” — a state of indifference to alcohol where cravings are diminished, and drinking becomes a true choice rather than a compulsion.

The speaker highlights that many people on TSM remain stuck because, although they follow the protocol, they are not internally ready to change their relationship with alcohol. Often, alcohol is deeply intertwined with identity, habits, and emotional coping. Without confronting these beliefs and fears, and without consistent alcohol-free days to retrain the brain, progress stalls. The Sinclair Method’s effectiveness hinges on “meeting the medication halfway,” meaning that alongside taking naltrexone, individuals must actively cultivate new rewarding behaviors and coping mechanisms to replace alcohol. Over time, this rewiring helps the brain reduce the motivation to drink and ultimately achieve a balanced, controlled relationship with alcohol.

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

This episode features a comprehensive Q&A session about the Sinclair Method (TSM) for addressing alcohol use disorder (AUD), hosted by Katie and Bruce, two experienced coaches working with individuals using this approach. The discussion centers on the unique, science-based mechanism of TSM, which uses the medication naltrexone (referred to as “nrexone” or “NTR”) to reduce alcohol cravings by targeting the brain’s endorphin addiction, rather than enforcing total abstinence. Bruce and Katie explain how alcohol triggers the release of endorphins—a natural brain chemical that produces pleasure and numbing effects—and how this neurochemical dependency fuels addiction. Unlike traditional abstinence-based treatments, which often fail due to intense cravings caused by removing alcohol (and thus endorphins) entirely, TSM allows controlled drinking while taking naltrexone to gradually “extinguish” the craving by breaking the endorphin-reward cycle.

They emphasize that TSM is a compassionate, forgiving, and flexible method that allows users to “press pause” during challenging life events, rather than forcing abstinence and self-denial. Naltrexone is taken about an hour before drinking to blunt the endorphin release, reducing the rewarding effects of alcohol and enabling gradual reduction or controlled drinking over time. The conversation also covers the importance of support structures, mindset work, counseling, and habit change alongside medication use. They discuss practical topics such as planning alcohol-free days, managing dosage timing, and differentiating between neurological addiction and psychological habit or emotional reliance on alcohol.

Bruce and Katie highlight that TSM success rates are around 78-80% when users are compliant with the medication protocol, and the program’s strength lies in combining neuroscience with behavioral change and emotional support. The dialogue also addresses common questions about supplements, the role of genetics in endorphin response, and how natural endorphin-producing activities (like exercise and social connection) can support recovery. The hosts encourage a kind, patient approach to recovery that includes self-compassion and realistic expectations, acknowledging that progress is gradual and nonlinear.

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

In this episode, Dr. Joseph Vachelli, a leading expert on Naltrexone (referred to as “NRE Zone” or “naltrexone” in the transcript) and alcohol use disorder (AUD), discusses the practical applications of daily versus targeted naltrexone use, particularly in the context of the Sinclair Method. He explains who benefits most from each approach, the underlying brain mechanisms involved in alcohol cravings, and the importance of psychosocial support alongside medication. Dr. Vachelli highlights that targeted naltrexone is suitable for individuals who binge drink or are in early stages of problematic alcohol use, whereas daily dosing often suits severe, habitual drinkers. He also emphasizes the genetic and phenotypic factors influencing response to naltrexone, and clarifies why timing and adherence matter. He underscores the complex interaction between the logical (cognitive) brain and the emotional (limbic) brain in decision-making related to drinking and treatment adherence. Finally, Dr. Vachelli stresses the importance of combining medication with social and psychosocial support for effective recovery.

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/

In this video, Dr. Joseph Vachelli, a leading expert on Naltrexone and the Sinclair Method, addresses a common question among users: whether it is necessary to drink alcohol after taking Naltrexone (referred to as “Nxone” or “Nrex Zone”) or if one can choose not to drink and still benefit from the medication. Dr. Vachelli clarifies that it is perfectly acceptable—and often beneficial—for individuals to take Naltrexone without drinking. The medication reduces cravings and helps extinguish conditioned responses to alcohol-related cues, even when no drinking occurs. This means that people can regain control and freedom over their drinking habits, either by drinking in a controlled manner or abstaining altogether, without feeling pressured or wasting the medication.

Dr. Vachelli explains the mechanism behind this effect, highlighting how Naltrexone blocks the reinforcement of drinking behavior and also diminishes cravings triggered by environmental cues, such as being in a bar or watching Netflix at home. Over time, these cues lose their power, allowing individuals to be in high-risk drinking situations without temptation. Importantly, the medication also helps expand sources of pleasure beyond alcohol, such as enjoying a cup of hot cocoa or the company of a partner.

Furthermore, Dr. Vachelli emphasizes the importance of psychosocial support—including coaches, peers, or recovery groups—as a critical complement to medication. Such support systems provide accountability, encouragement, and hope, which are key to long-term recovery. Overall, the Sinclair Method, combined with Naltrexone and social support, offers people choice and freedom from addiction rather than strict abstinence or dogma.

About Katie Lain

Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. 

*Links*

https://www.thrivealcoholrecovery.com/

https://tiktok.com/@thrivealcoholrecovery

https://youtube.com/@thrivealcoholrecovery/

https://www.instagram.com/thrivealcoholrecovery/

https://www.facebook.com/groups/thrivewiththesinclairmethod

https://www.linkedin.com/company/thrive-alcohol-recovery/

https://twitter.com/thrivewithtsm/