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Dr. Abhishek Mangeshikar explores how endometriosis severity varies globally, highlighting the interplay between genetics, environmental factors, and healthcare access. While genetic components exist in endometriosis development, expression is influenced by epigenetics including diet, stress, and environmental conditions that determine disease progression patterns.

• Endometriosis has a genetic component, but gene expression depends on epigenetic factors
• Environmental factors, diet, hormones, and physiological stress influence disease expression
• Healthcare access significantly impacts observed disease severity across regions
• Lower-income countries typically see more advanced disease due to delayed diagnosis
• Early intervention in higher-income countries often prevents progression of certain disease types
• More diverse, multicultural studies are needed to understand global endometriosis patterns

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