In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years.

We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.
Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your perimenopausal years can make all the difference for long-term health. Dr. Shepard shares the essential labs she runs on patients including ApoB, HbA1c, and thyroid optimization, plus the longevity metrics women should be tracking.
We also get into supplement recommendations including why she recommends 10 grams of creatine daily, the role of inflammation in aging, and how estrogen is naturally anti-inflammatory which is why women see increased cardiovascular risk and metabolic dysfunction after menopause.

Kayla's social + website:

Instagram:  kaylabarnes

TikTok:  femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn2...

Apple: https://podcasts.apple.com/us/podcast...

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Dr. Jessica Shepherd's social + website:

Website: https://www.jessicashepherdmd.com/

Instagram: https://www.instagram.com/jessicashepherdmd/

Transform Your Health: https://eudemonia.net/?utm_source=podcast&utm_medium=kayla-podcast&utm_campaign=jessica-shepherd

What if your blood is what’s making you sick and the key to reversing it is removing it?

In this episode, I sit down with Dr. Khanh Nguyen, a regenerative and anti-aging physician, to explore therapeutic plasma exchange and the rising use of young plasma. We talk detox, autoimmune disease, aging, peptides, and why your blood might be holding you back.

Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.

https://kayla-barnes-lentz.circle.so/...

Kayla's social + website:

Instagram:  kaylabarnes

TikTok:  femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn2...

Apple: https://podcasts.apple.com/us/podcast...

Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Khanh's social + website:

Instagram: https://www.instagram.com/regenwithdrnguyen/

Website: Austin Regenerative Therapy

Is your environment silently sabotaging your fertility?

Dr. Ann Shippy joins the show to reveal how hidden toxins, mold, and overlooked cellular damage may be accelerating ovarian aging and how to reclaim your fertility before it’s too late. From infertility misdiagnoses to rising autism rates, we dive deep into the tests most doctors never run, and the real impact your body’s toxic load has on future generations. 

Kayla's social + website:

Instagram:  kaylabarnes

TikTok:  femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn2...

Apple: https://podcasts.apple.com/us/podcast...

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Dr. Ann Shippy social + website:

Instagram: https://www.instagram.com/annshippymd/
Website: https://annshippymd.com/

Ashley Koff is a registered dietitian and author who spent 20 years discovering that weight and health aren't separate issues, they're connected through "weight health hormones." After her own struggles with restrictive eating despite doing everything "right," a functional medicine doctor helped her understand what was actually broken, and that was, her body's natural hormone function.

In this episode, Ashley explains why GLP-1 medications like Ozempic work, who actually needs them, and the critical foundational work required to avoid devastating rebounds. She reveals why current dietary guidelines fail women, shares her free weight health hormone assessment, cuts through the seed oil controversy, and offers practical strategies for eating healthy on any budget.

If you're confused about nutrition, frustrated that eating healthy isn't working, or curious about GLP-1 medications, this conversation provides the clarity you've been missing.

Guest’s socials + website:

Instagram: @ashleykoffapproved

Website: https://thebetternutritionprogram.com/ 

Kayla's social + website:

Instagram:  https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ

Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227

Follow Her Female Protocol:  https://www.protocol.kaylabarnes.com

Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

In this video, Dr. Will Bulsiewicz shares his transformation from an overweight, depressed gastroenterologist to a gut health expert after meeting his now-wife changed his entire approach to food. He reveals why 95% of Americans are fiber deficient and how this single nutrient could be the key to longevity. Dr. B breaks down the science of the gut microbiome, explains why hyperpalatable foods force us to overeat 500 extra calories per day, and shares actionable strategies for rebuilding your gut health in as little as 3-5 days.

Guest’s socials + website

Instagram: @theguthealthmd 

Website: https://theguthealthmd.com/ 

Kayla's social + website:

Instagram:  https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ

Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Women don’t fail January — January fails women. Nearly 80% of New Year health goals are abandoned within weeks, not because of discipline, but because most plans ignore female biology. That’s why I created the 30-Day Female Longevity Challenge — a physiology-first way to prepare calmly and build health that actually lasts. Save $50 with code 2026. https://kayla-barnes-lentz.circle.so/checkout/female-longevity-challenge-2026?coupon_code=2026When you join, you also get one full year access to my female membership for on-going accountability, my monthly AMAs, a female support community, access to my 20 other courses and more! Optimizing your home: https://www.youtube.com/watch?v=Ni5GFTRWjikHome inspection: https://www.youtube.com/watch?v=8si4I1Bt5nMAt home health tracking: https://www.youtube.com/watch?v=23RUCOpBCE8&t=235s

Kayla's social + website:

Instagram:  https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ

Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

In this conversation, Kayla sits down with Dr. Sarah E. Hill, PhD to talk about the science behind PMS, cycle syncing, and why most health advice completely fails women. Dr. Hill explains the three main causes of PMS symptoms, natural hormonal shifts, one-size-fits-all protocols designed for men, and lack of cellular resilience.

Join the most comprehensive female-specific community for health and longevity optimization. After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.

https://kayla-barnes-lentz.circle.so/...

Follow Dr Sarah: 

Instagram - https://g2ul0.app.link/KjuJon93HOb 

Twitter - https://g2ul0.app.link/UFHinMb4HOb 

Website - https://g2ul0.app.link/f3JSWDd4HOb

Kayla's social + website:

Instagram:    / kaylabarnes  

TikTok:   / femalelongevity  

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn2...

Apple: https://podcasts.apple.com/us/podcast...

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

For years, functional medicine has focused on lab results and supplement protocols. Dr. Deanna Minich knows there's a deeper layer most practitioners miss. As a nutrition scientist who worked under Dr. Jeffrey Bland and educated for the Institute for Functional Medicine, she's witnessed how artificial light at night disrupts women's hormones more than almost any other factor, yet it's completely ignored.
In this episode, Dr. Minich reveals why 85% of people are Omega-3 deficient despite supplementing, how eating a rainbow of 30+ plant species weekly rebuilds your microbiome diversity, and why your skin's "photo-metabolome" produces healing compounds from sunlight that Vitamin D pills can never provide. She explains the Goldilocks principle of sun exposure, why most women only get 11-15 grams of fiber daily when they need triple that, and how stress functions as a toxin that triggers leaky gut and impairs detoxification. Dr. Minich also shares why women's heightened sensitivity isn't a weakness but a powerful gift for intuition and healing.
If you're tired of functional medicine that stops at labs and supplements, this conversation offers a comprehensive framework integrating circadian optimization, creative expression, gut diversity, and the spiritual aspects of women's health that determine true longevity.Guest’s socials + website

Instagram: https://www.instagram.com/deannaminich/
Website: https://deannaminich.com/

Kayla's social + website:
Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter: https://x.com/femalelongevity
Website: https://www.kaylabarnes.com/

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/
Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Everyday “healthy” choices might be silently rewiring your immune system—from canned soup and tap water to perfume, makeup, and even your couch—while autoimmune diseases quietly explode, especially in women. In this gripping conversation, Dr. Aly Cohen reveals how under-regulated chemicals, hidden toxins, and epigenetic changes may be driving the autoimmune epidemic, but also how strategic swaps, smarter water, food, air, and a 4-A framework can actually change the destiny of your health. If you’ve ever wondered whether you can truly detox, reverse flares, and protect future generations, this episode turns overwhelming science into a suspenseful, empowering roadmap.

Join the most comprehensive female-specific community for health and longevity optimization. After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.

https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Kayla's social + website:

Instagram:  https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ

Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Aly's social + website:

Website: https://thesmarthuman.com/

Instagram: https://www.instagram.com/thesmarthuman/

X: https://x.com/thesmarthuman

Apple: https://podcasts.apple.com/us/podcast/the-smart-human-with-dr-aly-cohen/id1518816002

Spotify: https://open.spotify.com/show/2ETBDQQ1WWQiHPtvSphUXM?si=EhDPKBu7RWKBm7dqEWpgkQ&dl_branch=1&nd=1&dlsi=b8308d4428e0401d

In this episode, Kayla sits down with Dr. Karan Rajan, who is one of the most followed medical professionals on social media, and he breaks down the gut microbiome like you've never heard before. If you've ever felt bloated after eating fiber, tried keto and felt amazing temporarily, or wondered why your "clean" diet isn't delivering results, this episode is for you.
They talk about why fiber is non-negotiable fuel for your gut bacteria, how to gradually increase intake from 10g to 50g+ daily, and the specific prebiotic fibers that matter most. Dr. Rajan shares his daily eating protocol, explains why prebiotics trump probiotics, and reveals the critical differences between male and female microbiomes. You'll also learn his exact protocols for recovering from antibiotics, healing leaky gut and why fasting activates your gut's self-cleaning system. 

Guest’s socials + website
Instagram: @drkaranrajan
Website: https://www.drkaranrajan.com/

Kayla's social + website:
Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter: https://x.com/femalelongevity 
Website: https://www.kaylabarnes.com/
Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/
Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member