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Quinolones are a class of antibiotics that can be used for various infections. I discuss the pharmacology, adverse effects, drug interactions and other items on this podcast episode.
On this episode, I talk about the warnings associated with quinolones.
Quinolone use has subsided over time, not due to the fact that they are ineffective, but to rising concerns and warnings about adverse effects.
Quinolones can interact with quite a few medications. I’ve seen a case of amiodarone and levofloxacin contributing to QTc prolongation which I discuss on this episode.
It is critical to remember the binding interactions associated with quinolones as these can potentially lead to treatment failure.
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On this episode I discuss why we may need to use potassium supplements.
I also talk about a medication error situation involving potassium that lead to a death.
It is important to remember other medications that can raise potassium levels.
I also talk about a dosage form of potassium that might make patients ask some questions.
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On this episode, I talk about apixaban (Eliquis) pharmacology.
I also cover adverse effects like bleeding and what to monitor.
Drug interactions are a concern with apixaban and I discuss a few items that you may want to look out for.
It is important to remember that apixaban does require dose adjustments in certain situations as well.
Check out our free giveaway for healthcare professionals and students. It is a top 200 study guide of highly testable pearls! (Free 31 page PDF)
Metoclopramide can block dopamine receptors as part of it’s mechanism of action. I discuss the clinical implications from this in the podcast.
Metoclopramide can exacerbate Parkison’s disorder so you need to be careful in that type of patient.
Metoclopramide is dosed frequently, which can potentially be a downside as far as patient adherence goes.
Metoclopramide has a few potential interactions that you should be aware of. I talk about those in this episode.
Be sure to check out The Thrill of the Case on Amazon as I do have a clinical scenario about Reglan (metoclopramide) in that 200+ page book.
As always, check out my free Top 200 study guide!
On this episode, I discuss the mechanism of action of the SGLT-2 Inhibitors and how they lower blood sugar.
These drugs are classically used for diabetes and eliminate blood sugar through the urine.
One of the potential side effects is that these drugs can increase the risk of genital infections and urinary tract infections.
There is a boxed warning on canagliflozin for its potential to increase the risk of amputation.
These drugs also have a mild diuretic type effect and can potentially cause hypotension.
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Cheers!
Eric Christianson, PharmD, BCGP, BCPS
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