In this special episode of Skin Anarchy, host Dr. Ekta Yadav celebrates a milestone moment—her latest mini review, Inflammation and Aging: The Skin Inflammasome in the Context of Longevity Science, has been published in the Journal of Cellular Immunology. This episode offers listeners a deep but accessible dive into the mechanisms that link chronic inflammation, skin health, and the biology of aging.

Dr. Yadav unpacks the concept of “inflammaging,” explaining how low-grade, persistent inflammation accelerates skin aging and predisposes us to a host of conditions—from acne and psoriasis to pigmentation disorders. Central to this is the NLRP3 inflammasome, a cellular sensor that responds to both internal stress and external insults. But the conversation doesn’t stop at surface-level inflammation—it zooms out to show how NAD+ depletion, mTOR signaling, sirtuin activity, and cellular senescence all play a role in the skin’s aging clock.

Listeners will get a taste of the therapeutic landscape too—from the promise of repurposed drugs like metformin and rapamycin to the caution needed around immune modulation. Dr. Yadav also weaves in emerging research on gut-skin interactions and psychoneuroendocrine links, emphasizing the systemic nature of skin health in the context of longevity.

If you’re curious about the future of aging, biohacking, or the real science behind graceful skin longevity, this episode is a must-listen. Tune in to learn what’s next in skin biology—and why inflammation is more than just skin deep.

Read the full article HERE.

To learn more about Dr. Ekta, visit her social media.

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