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This conversation focuses largely on the work of the Global NASH Council, an effort of over 200 stakeholders in more than 50 countries to address a range of macro issues in the MASLD space.

Zobair Younossi, who is the Global NASH Council Chair, starts this conversation by discussing a specific Global NASH Council project on how to implement guidelines for different specialties across regions. He offers two reasons this is such an important project.

1. In general, Zobair notes, 90% of the content in guidelines is virtually identical, but the other 10% might vary widely. The goal of the Global NASH Council is to identify this last 10%, understand the reasons for these differences, and seek to align them better.
2. As he points out, guidelines are worthless without effective implementation. The second goal of this project is exactly that: to improve implementation.

Zobair goes on to discuss other Global NASH Council projects, ranging from shared biopsies to the previously mentioned modeling activities. He notes its growth in size and expresses gratitude to the other global MASLD leaders, including Jörn Schattenberg, who are part of one of more of the Council's major projects.

Roger Green asks Zobair to put the guidelines project and the Council's policy focus in the context of his earlier comments about high SDI vs. low SDI countries. He describes differences in what food insecurity means between the two types of nations and how that should affect each country’s pursuit of policy and guidelines. He also suggests that it will be more important to provide patient and provider information for specific low SDI countries.