South Africa's President Ramaphosa has opened a vaccine manufacturing site in Cape Town. The BBC's Vumani Mkhize was at the event, and brings us the details. And we get reaction to the development from Thomas Cueni, director general of the International Federation of Pharmaceutical Manufacturers and Associations in Basel. Also in the programme, the vice president of the European Securities and Markets Authority has called for a ban in the European Union on mining of the cryptocurrency Bitcoin, on environmental grounds. Erik Thedeen explains his thinking. Rising food and fuel prices are making daily life tougher for the people of Sri Lanka, and the BBC's Anbarasan Ethirajan reports on the difficulties people in the country face. Plus, less than 10 per cent of trade involving members of the East Africa economic bloc the EAC is currently delivered by rail. Tanzania and Burundi hope to change that and are planning a new rail connection between the two countries. We hear what the countries hope to achieve with the proposal from Nuzulack Dausen, executive editor of the NuktaAfrica news agency in Dar es Salaam.