Drs. Kavita Vakharia, surgical oncologist from City of Hope, Dr Sara Bateni, surgical oncologist at University of Alabama at Birmingham, Dr Nikhil Khushalanai, medical oncologist at the H. Lee Moffitt Cancer Center and James Jakub, surgical oncologist at the Mayo Clinic, Florida, discuss their current practice regarding multidisciplinary management of melanoma with a focus on the role of adjuvant systemic therapy for stages IIB, IIC and IIIA disease.