One of Hollywood's most versatile actors opens up about his discovery of improv en route to 'The Daily Show,' how a small part in 'Anchorman' led to a star-making role in 'The 40-Year-Old Virgin' which, in turn, saved the fledgling 'The Office,' and why he ventured into darker material with 'Foxcatcher,' for which he received an Oscar nom, and his newest film.

But first: Sandra Lee, the Daytime Emmy-winning TV host, bestselling author and first lady of New York, joins Scott to discuss 'RX Early Detection: A Cancer Journey with Sandra Lee,' an HBO documentary short about her battle with breast cancer.

Credits: Hosted by Scott Feinberg, recorded and produced by Matthew Whitehurst.

Learn more about your ad choices. Visit megaphone.fm/adchoices