In the final episode of 2025, Matt Cohen and John Ruffolo reflect on a turbulent year for technology, capital markets, and Canadian innovation, while looking ahead to the forces that will shape 2026. The conversation opens with Canada’s largest private startup round of the year, a $1.76B raise by Toronto based HydroStar Energy Storage, and uses it as a springboard to examine the AI shakeout now underway. John describes the sector as entering a “forest fire” phase, where overfunded and undifferentiated companies fall away, creating room for stronger, more durable players to emerge.

Matt and John then explore whether 2026 will finally mark a return of major tech IPOs, or whether the regulatory burden and liquidity options in private markets will keep companies like SpaceX, Stripe, and OpenAI on the sidelines. Despite interest rate cuts, the hosts argue capital markets remain constrained and selective.

The discussion shifts to Canada’s strategic priorities, including a growing focus on defense technology viewed through a dual use lens of sovereignty and innovation. As talent emigration rises and domestic risk capital lags, the episode closes with a clear warning. Without addressing capital access, taxation, and long term retention, Canada risks becoming a leaky boat, losing its builders and economic future to the United States.

The 2025 AI Shakeout & The 2026 Forest Fire (02:06)

John predicts a period of simultaneous “carnage” and opportunity in AI, comparing the market to a forest fire that burns the weak but creates fertile ground for the strong. They debate which companies are the true “sequoias” built to last.

IPO or Bust? The Reluctant March to Public Markets (04:57)

With rumors swirling around SpaceX, Anthropic, and OpenAI, Matt and John explore why 2026 might see major IPOs. John argues that many are driven not by ambition, but by investor pressure for liquidity, calling it a “panacea” for fund timelines rather than a strategic goal.

Rate Cuts & Stagnation: Why Cheap Money Isn’t Fixing Canada’s Economy (07:28)

Despite multiple rate cuts in 2025, investment activity remains sluggish. The hosts diagnose a holding pattern for Canada’s economy, where further cuts risk devaluing the dollar without spurring meaningful productivity gains.

Bullets, Bombs, and Blockchain: Canada’s New Defense Tech Mandate (08:17)

Matt highlights new government funds for defense tech. John reframes the spending as critical for “physical sovereignty” in a tech-driven Cold War, emphasizing the “dual-use” nature of investments in AI, quantum, and satellite technology.

Predictions for 2026: Agents, Physical AI, and Nuclear’s Comeback (11:23)

The hosts share their forecasts: Matt bets on AI “agents” automating complex workflows and tangible ROI finally hitting enterprise software. John is bullish on “AI meeting the physical world” through robotics and autonomous machinery, and predicts a major comeback for nuclear energy.

Canada’s Leaky Boat: The Capital and Talent Retention Crisis (18:32)

Addressing record-high emigration, John identifies the twin failures crippling Canadian innovation: a lack of domestic risk capital at scale and an uncompetitive personal tax regime. He warns that without urgent fixes in the next budget, the brain drain will accelerate, with U.S. capital actively pulling companies and founders south.

Connect with John Ruffolo on LinkedIn: https://ca.linkedin.com/in/joruffolo

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, Matt Cohen and John Ruffolo break down a pivotal week for Canada’s innovation economy. Microsoft’s $7.5 billion investment in Canadian AI and cloud infrastructure sets the stage for a deeper discussion about whether foreign hyperscalers can genuinely support Canadian data and AI sovereignty under U.S. laws like the Cloud Act.

John challenges the assumption that scale equals sovereignty, arguing for a more intentional strategy built through government procurement, layered infrastructure, and selective partnerships. The episode also examines Canada’s new Quantum Champions program and the funding directed toward companies Anyon Systems, Xanadu, Photonic, and Nord Quantique, questioning whether current capital levels are enough to prevent Canadian breakthroughs from moving south.

Layoffs across the consulting industry surface broader shifts in knowledge work, as information becomes increasingly commoditized in the age of AI. Matt and John discuss how trust, execution, and implementation are replacing traditional advisory models as the real sources of value. The episode closes with a collision of crypto and legacy power, as stablecoin issuer Tether pursues a controlling stake in Juventus, raising new questions about regulation, asset backing, and trust.

As foreign capital pours in and domestic funding lags, how much control does Canada actually retain?

Microsoft’s $7.5B Canadian AI Investment & the Sovereignty Question (01:04)

Microsoft announces a massive investment to expand AI and cloud infrastructure in Canada. Matt and John unpack why foreign capital is welcome, but claims of “sovereign AI” raise serious concerns under the U.S. Cloud Act and data jurisdiction realities.

Sovereign Compute Strategy: Procurement Over Promises (04:39)

John outlines how Canada could realistically build sovereign compute capacity by breaking the stack into layers, using government procurement to back domestic players, and making intentional choices about allies, chips, and infrastructure.

Canada’s Quantum Champions Program: A Signal or a Solution? (07:49)

The federal government commits funding to four Canadian quantum startups, including Xanadu. The discussion explores whether milestone-based funding is enough or if Canada risks losing its quantum leaders to U.S. capital markets again.

Why Canadian Capital Isn’t Backing Its Winners (09:04)

Xanadu’s SPAC decision becomes a case study in Canada’s capital formation problem. John explains why strong companies still struggle to raise meaningful domestic capital and what that means for long-term value creation.

Consulting Firms Face Layoffs as Demand Shifts (11:36)

McKinsey and other professional services firms prepare for significant job cuts. Matt and John discuss overhiring during COVID, slowing demand, and how AI is compressing the value of information-based consulting.

The End of the Traditional Consulting Pyramid (14:07)

AI-driven efficiency challenges the apprenticeship model. The conversation explores why implementation and trust now matter more than slide decks and why junior-heavy consulting structures may no longer work.

Forward-Deployed Engineers & New Service Models (16:17)

From Palantir’s FDE approach to new AI-enabled services firms, Matt highlights how execution-first models are eroding traditional consulting margins and reshaping enterprise problem-solving.

Crypto Meets European Dynasties: Tether & Juventus (19:00)

Tether’s attempted acquisition of Juventus sparks debate around stablecoin backing, asset quality, and trust. John questions whether a treasury-backed stablecoin should ever be tied to assets like football clubs.

Trust as the Core Currency of the AI Era (21:03)

The episode closes with a clear takeaway: information is cheap, execution is hard, and trust is everything, from sovereign infrastructure to consulting, investing, and crypto.

Connect with John Ruffolo on LinkedIn: https://ca.linkedin.com/in/joruffolo

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, host Matt Cohen sits down with global venture capitalist Alex Lazarow, founder of Fluent Ventures, to unpack the future of early-stage investing as AI, globalization, and shifting economic forces reshape the startup landscape. Alex brings a rare perspective shaped by 20+ markets across Africa, Latin America, Europe, and Asia, plus experience backing seven unicorns, from Chime to breakout fintechs worldwide.

Alex shares insights from his unconventional path from academia-curious economist to McKinsey consultant, impact investor at Omidyar Network, partner at global firm Cathay Innovation, and now solo GP building a research-driven, globally distributed early-stage fund. He dives into why the best startup ideas no longer come from one geography, why AI has permanently rewritten the cost structure of company building, and how proven business models are being successfully reinvented in emerging markets and then exported back to the U.S.

He also breaks down why small businesses may become more powerful than ever, the rise of “camel startups,” and what founders everywhere must understand about raising capital in a world where early traction matters more than ever.

Whether you are a founder, operator, or investor navigating the next era of innovation, this conversation reveals how global patterns, AI tailwinds, and disciplined research can uncover tomorrow’s winners.

From Winnipeg to Wall Street: Early Career Lessons (00:01:17)

* Alex reflects on growing up in Winnipeg and navigating a multicultural family background.

* How early roles at RBC M&A and the Bank of Canada shaped his analytical lens.

* Why he pursued economics, consulting, and academia before landing in venture.

* The value of testing career hypotheses instead of blindly following one path.

Building a Global Perspective Through McKinsey (00:06:42)

* Alex describes working in 20 markets, from Tunisia during the revolution to Indonesia and Brazil.

* Why exposure to varied cultures and economies sharpened his ability to spot emerging global patterns.

* The framework he used to choose projects: people, content, geography.

Entering Venture Through Impact Investing (00:08:05)

* Joining Omidyar Network to explore fintech innovation and financial inclusion.

* Early exposure to global mobile banking and super-app models.

* The origin story behind investing in Chime.

* Why mission-driven investing shaped his lifelong global investment thesis.

Scaling Globally at Cathay Innovation (00:13:14)

* Transitioning into a traditional VC role after Omidyar.

* Helping scale Cathay from a $287M fund to nearly $1B.

* Why he eventually left to build a more focused, research-driven early-stage fund.

The Fluent Ventures Thesis: Proven Models, Global Arbitrage (00:16:45)

* Fluent backs founders who take validated business models and execute them in new geographies or industries.

* Investing between pre-seed and Series A with a tightly defined “10 business model portfolio.”

* Why their TAM is intentionally much smaller, only 200–500 companies worth meeting each quarter.

* Leveraging a network of 50 unicorn founders and global VCs to discover breakout teams early.

Why AI Is Reshaping Early-Stage Investing (00:23:01)

* AI has dramatically reduced the cost of building early products.

* Increasingly, startups raise capital after launching revenue not before.

* The new risk: foundational AI models may “eat” many SaaS products.

* What types of companies will survive AI disruption.

The Camel Startup & The Great Diffusion (00:28:14)

* The “camel startup” concept: resilient, capital-efficient companies built outside Silicon Valley norms.

* How software (and now AI) lets small companies “rent scale” once only available to big enterprises.

* Why the next decade will favor startups that focus on durability, not blitzscaling.

Why Silicon Valley Still Matters, Even for Global Founders (00:32:47)

* Alex encourages founders to build in their home markets but visit Silicon Valley to raise capital and absorb cutting-edge ideas.

* How one founder raised SF-level valuations while building in the Midwest.

* The “global arbitrage” advantage: raise capital where it’s abundant, build where costs are low.

Where Global Markets Are Leading Innovation (00:35:41)

* Why Japan is 5–10 years ahead in generational small-business transitions.Examples of B2B marketplace models thriving in India and now being imported to the U.S.

* How construction marketplaces, industrial marketplaces, and embedded fintech platforms are spreading across continents.

About Alex Lazarow

Alex Lazarow is the founder and Managing Partner of Fluent Ventures, an early-stage global venture fund investing in proven business models across fintech, commerce enablement, and digital health. A veteran global investor, Alex has backed seven unicorns, authored the award-winning book Out-Innovate, and previously invested at Omidyar Network and Cathay Innovation. He has worked in more than 20 countries and teaches entrepreneurship at Middlebury Institute.

Connect with Alex Lazarow on LinkedIn: linkedin.com/in/alexandrelazarow

Visit the Fluent Ventures website: https://www.fluent.vc/

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, Matt Cohen is joined by Samir Kaji, CEO and Co-Founder of Allocate, to break down the explosive growth of private market investing and why trillions in new capital are about to reshape the entire wealth ecosystem. Fresh off a $30.5M Series B, Samir unpacks how Allocate is building the missing infrastructure connecting fund managers, RIAs, and the next generation of investors, solving the painful workflows, broken data pipes, and manual processes still holding the industry back. From intelligent deal discovery and auto-filled subscriptions to AI-powered diligence and portfolio personalization, Samir explains how technology will unlock access, efficiency, and liquidity at scale for both advisors and allocators.

He also dives deep into the current venture cycle, the AI valuation frenzy, and the widening gap between mega-funds and emerging managers. Samir gives an unfiltered look at where the real opportunities lie, why liquidity is the next trillion-dollar unlock, how secondaries will redefine private markets, and what investors should be watching heading into 2030. If you want to understand where private markets, wealth management, and alternative investing are truly headed, this episode is essential listening.

The Origin Story: 25 Years Watching the Market Shift (03:09)

* Samir’s work at SVB and First Republic observing the decline of IPOs

* Cloud computing’s impact on fund proliferation

* Early signs that private markets needed new infrastructure

* How HNWIs and family offices began demanding access decades before the rails existed

Why Allocate Exists & What It Actually Solves (07:04)

* The fragmented “dark forest” problem of GP <> RIA connectivity

* Why wealth advisors can’t scale alt allocations using PDFs and lawyers

* The three pillars of Allocate

How Advisors Use Allocate to Scale 10x Without Adding Headcount (14:18)

* Auto-filled subs, KYC, allocation setup, client mapping

* Helping advisors serve all 150 clients, not just the top 20%

* Improving revenue while slashing operational drag

Unlocking Liquidity: The Biggest Missing Piece of Private Markets (21:16)

* Why secondaries are essential for opening the wealth channel

* Borrowing against private fund positions

* How tech will reduce massive bid-ask spreads

* Why liquidity options will double alt allocations from 5% → 10-30% over time

AI’s Real Role in Private Markets (25:20)

* AI as the intelligence layer for discovery, diligence & personalization

* Uploading 10 fund decks → receiving full breakdowns in minutes

* Why workflows, not chatbots, will unlock trillions

* Execution, payments & portfolio modeling going from days to seconds

The State of Venture Capital in 2025 (32:17)

* Why today’s market is “the extreme Tale of Two Cities”

* AI startups raising at insane velocity vs. great non-AI companies starving

* Why 90% of AI companies won’t justify valuations

* Seed funds getting squeezed by mega-funds writing “option checks”

* How emerging managers can still win (go earlier or niche down hard)

Founder Discipline, Revenue per Head, & the New Efficiency Era (40:06)

* Revenue-per-employee as the new defining KPI

* Why scarcity birthed a healthier generation of founders

* Companies going from 5 → 50 → back to 20 employees

* Running lean with AI as leverage instead of headcount

About Samir Kaji

Samir Kaji is the Co-Founder and CEO of Allocate, a platform revolutionizing how investors access and manage private market investments. With a career in venture banking spanning over two decades at Silicon Valley Bank and First Republic, Samir has an unparalleled view of the venture capital and private equity landscapes. He is also a Kauffman Fellow, the host of the Venture Unlocked podcast, and a personal investor in companies like Carta and Reddit. He remains dedicated to Allocate’s mission of making the private markets as transparent and responsible as the public markets.

Connect with Samir Kaji on LinkedIn: https://www.linkedin.com/in/samirkaji

Visit the Allocate website: https://allocate.co/

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, host Matt Cohen sits down with Chris Canavan, founder and general manager of Canavan Private Wealth, to unpack one of the most confusing and emotionally charged chapters in a founder’s journey: life after the liquidity event.

Chris brings thirty years of global institutional and private office experience to the table, but his superpower is not managing money. It is designing and running the system around a founder’s wealth. After watching countless entrepreneurs exit their companies only to be overwhelmed by advisors, decisions, documents, and emotional pressure, Chris built a model that restores clarity, control, and purpose.

He explains how founders lose sight of their instincts amid a fire hose of new advisors promising the world, why trust erodes so quickly after a deal closes, and how fragmented systems lead to panic, confusion, and poor decisions. Chris breaks down the architecture of a modern private office, why most founders rely on sticky notes and spreadsheets, and how his closed-loop operational model gives founders their time back.

From early warning signs of wealth fragmentation, to the psychological crash founders face when purpose suddenly disappears, to his triage process for investment opportunities, Chris delivers a brutally honest guide to navigating life after the big exit.

Whether you are preparing for a liquidity event or already living through the post-sale fog, this episode shows you what founders get wrong, what they must put in place, and how to build a system that supports your next chapter rather than suffocates it.

Spotting the Gaps: Managing the System, Not the Money (03:38)

* How advisory silos fail ultra-high net worth individuals

* Why communication, not talent, is the biggest weakness in wealth management

* The role of the generalist who understands every silo deeply enough to connect them

* Why founders need someone three to seven feet deep across all disciplines

Finding the Right Clients and Building Trust-Based Relationships (07:06)

* Why fit, values, and authenticity matter more than money

* How Chris screens clients who actually want to be helped

* Why some founders treat advisors like commodities and how that destroys outcomes

* Building long-lasting relationships built on accountability and transparency

Managing Founder Emotions and Behaviors Post-Exit (09:00)

* Founders are used to speed, scale, and instant execution

* Why slowing down is the hardest adjustment

* How Chris handles frustration, urgency, and emotional volatility

* The importance of respect and boundaries when multiple advisors and egos collide

Early Warning Signs of Wealth Fragmentation (16:21)

* When day-to-day tasks start consuming founder’s mental bandwidth

* The “black flies in cottage country” analogy

* Why founders lose the ability to focus on what matters

* The fire hose of advisors and opportunities after an exit

How Chris Evaluates Investment Opportunities for Clients (25:09)

* Pain reliever vs. gain creator: the framework for evaluating pitches

* Why relationships and trust matter more than projected returns

* How Chris filters noise before presenting anything to a founder

* The story-first, numbers-second diligence process

The Psychological Crash After a Big Exit (28:17)

* Why life will never be the same after selling a company

* How society begins to define founders by the name of their exit

* The loneliness and loss of identity that shock new millionaires

* Why every human needs a sense of purpose to avoid emotional collapse

Becoming a Project Manager of Your Own Life (31:45)

* Why successful entrepreneurs struggle when their team disappears

* Trust-building, listening, and meeting founders where they areHow Chris transitions from advisor to integratorWhy trust cannot be demanded, only earned over time

Advice for Founders Preparing for an Exit (36:48)

* Why founders must build structure before signing final documents

* The danger of early engagement with performance-focused advisors

* Why founders need an unconflicted advisory boardHow to breathe, slow down, and avoid urgency-driven decisions

The Future of Private Wealth for Canadian Founders (40:10)

* Why founders will disrupt the private office industry

* The coming shift from advice to execution

* How operational efficiency will redefine wealth managemen

* The democratization of systems once reserved for legacy families

About Chris Canavan

Chris Canavan is the founder and General Manager of Canavan Private Wealth, a private office that provides institutional discipline and operational clarity to ultra-high-net-worth individuals. With a background at global institutions and Big Four firms, Chris specializes in helping founders navigate the complex transition after a liquidity event by managing the systems around their wealth, coordinating advisors, and helping them find renewed purpose.

Connect with Chris Canavan on LinkedIn: https://www.linkedin.com/in/chrislcanavan/

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, host Matt Cohen is joined by John Ruffolo for an in-depth discussion on the latest business innovation news, cutting-edge tech developments, and disruptive market shifts that are shaping the global innovation economy. From game-changing legal tech acquisitions to the next big wave in quantum computing, the two break down the trends transforming Canadian fintech and the rise of stablecoin regulation. They also dive deep into AI advancements, big tech strategies, and the future of payments, offering fresh insights and actionable takeaways.

Clio’s Billion-Dollar Acquisition & Vertical Expansion in Legal Tech (01:38)

In a major legal tech acquisition, Clio secures a $5 billion valuation following its acquisition of vLex, expanding its role as a dominant player in the legal technology sector. Matt and John discuss how this deal positions Clio alongside industry giants like Thomson Reuters and LexisNexis and explore the risks and rewards of a vertical integration strategy.

Toronto’s Quantum Tech Breakthrough: SPAC Merger with Crane Harbor (05:11)

Toronto-based Xanadu Quantum Technologies makes headlines with its SPAC merger with Crane Harbor Acquisition Corp., paving the way for the first-ever Canadian quantum tech debut on the TSX and NASDAQ. John shares exclusive insights into the company’s growth trajectory and how the merger will impact the quantum computing industry.

Elon Musk’s Trillion-Dollar CEO Package: Will He Become the First Trillionaire? (09:05)

Matt and John dive into the details of Elon Musk’s massive CEO package, designed to potentially turn him into the first trillionaire. They analyze the massive financial goals Musk must achieve and the broader economic impact this deal could have on industries like electric vehicles, space tech, and AI innovation.

Google and Apple’s AI Partnership: What Does It Mean for Siri? (12:21)

A landmark deal between Google and Apple will see Google’s Gemini AI powering Siri’s next-generation intelligence. Matt and John discuss the implications of this collaboration for artificial intelligence, cloud computing, and the future of voice assistants in the consumer tech market.

Robinhood’s New AI Fund: The Risks of Retail Investor FOMO (15:14)

In a bold move, Robinhood announces plans to give retail investors access to private AI companies. While this could open up private equity investments to the masses, Matt and John debate the risks of retail investor FOMO and the potential impact of AI investment bubbles on individual portfolios.

Visa & Mastercard Lowering Interchange Fees: The Impact on Credit Card Rewards (16:39)

In a significant shift, Visa and Mastercard are negotiating a deal to lower interchange fees, a change that could fundamentally alter the credit card rewards system. John explains the long-term effects on merchant relationships, consumer rewards, and the potential disruption of traditional payment systems as blockchain technologies emerge.

Connect with John Ruffolo on LinkedIn: https://ca.linkedin.com/in/joruffolo

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, host Matt Cohen is joined by John Ruffolo and special guest Mark McQueen, Founder of Wellington Growth Partners and one of Canada’s leading voices on capital markets and policy, as they dive into Canada’s 2025 Federal Budget. Together, they unpack the implications of Ottawa’s newly tabled “Building a Stronger Canada” budget, one that promises $1 trillion in investment over five years, with a heavy focus on productivity, infrastructure, defense, and innovation.

The three dissect everything from the $78B deficit and 40,000 public service cuts, to new measures for AI, fintech, and open banking. Mark brings a pragmatic lens to the table, calling out where policy meets politics, and where Canada’s ambitions fall short compared to U.S. spending.

They debate whether this really is the “FinTech Budget,” explore the Bank of Canada’s new stablecoin oversight, and discuss how Canada’s pension funds, capital markets, and innovation ecosystem might respond. The conversation also touches on AI infrastructure, quantum tech, and the Build Canada Exchange, before ending with an analysis of the surprise party floor crossing in Parliament and what it signals about political volatility ahead of the next election.

This is a data-driven, no-spin breakdown of the biggest budget in Canadian history, filled with insights for founders, investors, and policymakers navigating the next decade of Canadian innovation.

Market Reactions and Fiscal Discipline (01:51)

* How the bond market’s muted reaction signals investor confidence

* What a 3.07% 10-year yield says about fiscal credibility

Political Optics and Policy Recycling (03:16)

* Mark’s take on why budget speeches feel like déjà vu from 2016

* How repeating “middle-class growth” messaging masks deeper issues

Canada’s AI Spending Reality Check (05:39)

* $186M in new AI funding versus $207B in U.S. venture capital

* Mark calls Canada’s AI plan a “rounding error” in global competition

Housing, Media, and Missed Opportunities (07:26)

* Why Canada’s housing policy still taxes development and stifles growth

* How inflated consultant costs drain infrastructure progress

Private Capital and the $500B Question (08:51)

* Mark explains why private-sector “recycling” of assets rarely works as advertised

* The hidden costs behind selling public infrastructure

The Rise of the FinTech Budget (13:15)

* John calls this the “FinTech Budget” for its zero-cost innovation plays

* How open banking and stablecoin regulation could unlock private innovation

Policy Over Capital: A New Model (14:46)

* Why regulation, not spending, may be the most powerful innovation tool

* How Minister Champagne’s policy shift empowers private players

The Stablecoin Debate (17:46)

* John explains tokenization and one-for-one backing of digital assets

* Mark questions whether consumers can truly distinguish trust in DeFi

Canada’s Shot at Becoming “Switzerland of DeFi” (21:01)

* How upcoming legislation could make Canada a global leader in digital finance

* Why trust, not capital, is Canada’s biggest competitive advantage

Why Execution Matters More Than Promises (27:04)

* Matt, John, and Mark close with a reality check: policy means nothing without follow-through

* Why 2025 will test whether the government can turn big ideas into real results

About Mark McQueen

Mark McQueen is a veteran Canadian venture capitalist, financial commentator, and former Chair of the Toronto Port Authority. As President and Executive Managing Director of Wellington Financial LP, he has financed hundreds of high-growth companies across North America and is known for his sharp insights into capital markets, infrastructure, and public policy. A regular contributor to BNN Bloomberg and The Toronto Star, Mark offers a pragmatic, data-driven perspective on how fiscal decisions and government budgets shape Canada’s innovation economy.

Connect with Mark McQueen on LinkedIn: https://www.linkedin.com/in/mark-r-mcqueen/

Connect with John Ruffolo on LinkedIn: https://ca.linkedin.com/in/joruffolo

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, host Matt Cohen sits down with Roberto Bellini, Co-Founder of BSQUARED Capital and former CEO of Bellus Health, for a powerful conversation about family, legacy, and resilience in the world of biotech.

Originally recorded just two weeks before the passing of his father, Dr. Francesco Bellini, one of the founding giants of Canadian biotech, this re-recorded episode serves as a moving tribute to the man known as “Mr. Biotech Canada.” Roberto opens up about what it was like growing up under the guidance of such a visionary figure and how that experience shaped his own path as an entrepreneur and leader.

He reflects on the highs and lows of leading Bellus Health, from moments of near collapse to its remarkable $2 billion acquisition by GSK, sharing lessons on risk-taking, perseverance, and the importance of staying grounded through uncertainty. Roberto also offers his perspective on the future of Canadian biotech, highlighting the need for stronger late-stage funding and how BSquared Capital is helping to cultivate the next generation of innovators.

This episode isn’t just about business success; it’s about honoring a legacy, learning through adversity, and discovering what it truly means to build something that endures.

The Legacy of Dr. Francesco Bellini (00:02:52)

* Francesco Bellini’s incredible immigrant story: from arriving in Canada with nothing to a $6B biotech exit.

* Business was the family’s dinner table conversation, and attending AGMs as a child.

* The founding of Biochem Pharma and the discovery of the groundbreaking HIV treatment.

* “He was a visionary... he saw things before other people saw them.”

Growing Up in Biotech (00:06:30)

* Roberto’s early memories of board meetings and dinner-table business lessons

* How being “in the room” shaped his entrepreneurial mindset

* Watching a $6B biotech deal become part of family history

The Rise, Fall, and Rebirth of Bellus Health (00:08:27)

* Roberto’s journey from family office analyst to a 30-year-old, first-time CEO of a public company.

* The devastating failure of the phase three trial for a rare kidney disease.

* Inside a Biotech Failure: The intense, weekend-long “war room” process of unblinding clinical trial data and preparing for a public announcement.

The Second Act: Finding the Cough Drug (00:13:47)

* Discovering a promising molecule through the NeoMed Institute

* Betting the company’s future on a last-chance asset

* Raising $20M when no one believed and turning it into a $2B success

Negotiating the GSK Deal (00:24:45)

* The strategic shift from “build-to-sell” to “build-to-scale”, positioning the company for a premium acquisition.

* The M&A Playbook: Why you should never lead with a desire to sell; the importance of building for independence.

* The high-stakes negotiation with GSK: going from an $11 offer to $14.75, almost losing the deal, and the “mellow tone” that saved it.

* The entrepreneur’s dilemma: “Every single entrepreneur I’ve met that sold their company, there’s always a moment of not wanting to do it.”

Building Canada’s Biotech Future (00:30:11)

* Why Canada has the innovation but lacks the enduring biotech giants.

* The critical gap: The need for more late-stage capital and the role of Canadian pension funds.

* The “Gilead of the North” vision: Creating a virtuous cycle of capital, entrepreneurs, and translational science.

* Upcoming trends: The convergence of AI and drug discovery to de-risk development and lower costs.

Beyond the Lab: Leadership, Risk, and Legacy (00:46:20)

* Learning to embrace risk and find joy in reinvention

* The best advice from Dr. B: “Spend your money, it’ll make you want to earn more.”

* Why true success isn’t just building a company, but building people

About Roberto Bellini

Founder & Managing Partner, BSQUARED Capital

Roberto Bellini is a second-generation biotech entrepreneur and investor. As the former CEO of Bellus Health, he led the company’s dramatic turnaround and eventual $2 billion acquisition by GSK. Drawing on his deep operational experience in drug development, he now co-manages BSQUARED Capital, a family office focused on investing in and supporting promising biotech ventures. He is a passionate advocate for building a stronger, more resilient biotech ecosystem in Canada.

Connect with Roberto Bellini on LinkedIn: https://www.linkedin.com/in/robertobellini/

Visit BSQUARED Capital Website: https://bsq-c.com/

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, host Matt Cohen is joined by John Ruffolo to break down the week’s biggest stories shaping the innovation economy. From the Bank of Canada’s surprise rate cut to Meta’s $200B market crash, and the rise of Canada’s fintech and stablecoin revolution. They kick off with a spotlight on Waterloo’s AI-powered baseball tech that’s changing Major League play, before unpacking the renewed U.S.-Canada tariff tensions and what the Bank’s fourth rate cut signals for inflation, growth, and fiscal strategy ahead of the November 4th budget. The two also dive deep into the stablecoin boom, Mastercard’s $2B bet on crypto infrastructure, and how Ottawa is scrambling to keep pace with the U.S. Genius Act and its implications for the future of Canadian payments.

Matt and John then turn to Wealthsimple’s record-breaking $10B valuation and what it means for Canada’s domestic market opportunity, before dissecting Meta’s controversial accounting maneuvers that wiped out $200B in market cap. They close by exploring OpenAI’s trillion-dollar restructuring, Microsoft’s 20x return on investment, and the race among tech giants to fund the next phase of AI infrastructure. It’s a sharp, data-packed Rundown filled with fresh insights on capital markets, emerging technologies, and the power shifts redefining global innovation.

Waterloo’s AI Baseball Revolution (01:08)

* How a University of Waterloo startup is changing the game with AI-powered pitching machines

* The rise of Tradex Sports and MLB’s tech adoption

* What this means for Canada’s sports innovation ecosystem

U.S.-Canada Tariff Tensions Rise Again (03:25)

* The Senate votes to nullify tariffs on Canada, but Trump’s volatility looms large

* The politics behind tariff rollbacks

* Why Canada’s “elbows up” strategy backfired

* What this means for trade and cross-border investors

Bank of Canada’s Fourth Rate Cut (06:33)

* Governor Tiff Macklem cuts rates by 25bps. Is this the end of the easing cycle?

* Inflation, weak GDP, and the limits of monetary policy

* Why fiscal stimulus might be the only lever left

* What to watch on November 4th as markets react

Canada’s Stablecoin Race Heats Up (09:10)

* Stablecoins triple Visa’s volume: Can Canada keep up with the U.S.?

* Mastercard eyes $2B Zero Hash acquisition

* Inside Ottawa’s urgent push for stablecoin regulation

* The rise of “sovereign blockchains” and real-time rails

The Future of Payments Canada (14:34)

* Why the nation’s 10-year-late “Real-Time Rails” might already be outdated

* How blockchain will reshape payment infrastructure

* The hidden trillions moving on ancient financial rails

Wealthsimple’s $10B Milestone (16:17)

* A Canadian fintech unicorn doubles its assets in one year

* Lessons from its Series E and $750M raise

* Why Canada’s domestic market is finally worth betting on

Meta’s $200B Accounting Meltdown (20:04)

* Zuckerberg’s AI spending spree and the fallout from “funny accounting”

* Why investors are calling out Meta’s SPV strategy

* What this says about the next phase of Big Tech CapEx wars

OpenAI’s $1 Trillion Restructure (24:06)

* Inside the new deal that redefines AI ownership and governance

* How Microsoft turned a $13B bet into a 10x gain

* Why this could become the most lucrative investment in tech history

Connect with John Ruffolo on LinkedIn: https://ca.linkedin.com/in/joruffolo

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

In this episode of Tank Talks, host Matt Cohen sits down with Sameer Dhar, Co-Founder and CEO of NiaHealth, to explore how proactive healthcare is reshaping the future of medicine.

Sameer shares his remarkable journey from living in nursing homes for a year while building his first startup (Sensassure) to launching NiaHealth, a Canadian health-tech company empowering people to take ownership of their longevity through AI-driven diagnostics and personalized insights.

With over $8 million in funding and a 12,000-person waitlist, NiaHealth is building a clinician-first model that complements Canada’s public system, helping users prevent disease decades before it develops. Sameer also discusses why prevention, not treatment, must drive the next wave of healthcare innovation, how AI will augment rather than replace clinicians, and what it takes to build a mission-driven company in a regulated industry.

Whether you’re a founder, investor, or health enthusiast, this conversation reveals how the next generation of health tech startups can blend AI, clinical integrity, and human empathy to create lasting impact.

A Quick Word from our Sponsor, Fasken

At Fasken, our clients don’t wait for the future. They build it. As the first and largest dedicated emerging tech practice in Canada, our team is composed of founders, ex in-house counsel, developers and business advisors who have guided clients from startup, to scale-up, to exit. The trust of our clients has enabled us to consistently rank at the top of every major Canadian M&A, Capital Markets and Venture Capital league table. With deep industry knowledge and experience across all areas of emerging and high growth technology including ClimateTech, MedTech, Artificial Intelligence, Fintech, and AgTech we’re your partners within the innovation ecosystem as you transform the landscape of what’s possible.

Tomorrow starts here. Own it with us.

For more information, visit fasken.com/emergingtech and follow us on LinkedIn.

The Entrepreneurial Spark (05:52)

* How the Next 36 program transformed Sameer from a finance student into a founder

* The power of founder-focused education in shaping Canada’s startup ecosystem

* Lessons from learning to “think like a builder” instead of an employee

From Customer Discovery to Conviction (10:46)

* How customer discovery can turn into “analysis paralysis” if you never act

* Why true innovation means taking bold bets, not just collecting insights

* The importance of timing when moving from research to execution

Building NiaHealth (13:26)

* The personal mission to keep people healthy long before disease develops

* How the pandemic revealed gaps in personal healthcare ownership

* The evolution of NiaHealth into a platform offering advanced diagnostics, clinician reviews, and personalized longevity plans

Integrating with the System (17:12)

* Why NiaHealth chose a “clinician-first” model rather than going fully digital

* How nurse practitioners bridge the gap between data and diagnosis

* The importance of integrating with Canada’s public system to maintain trust

Trust and Transparency (22:51)

* Addressing criticism about private healthcare models in Canada

* Why NiaHealth avoids affiliate sales to maintain clinical integrity

* The company’s research-led approach to responsible, evidence-based testing

Filling the System’s Blind Spots (26:13)

* Canada’s biggest blind spot: a reactive healthcare model built around disease

* How prevention and early diagnostics reduce system strain and save lives

* The mission to empower users to act on health risks decades in advance

AI as an Enhancer, Not a Replacement (29:16)

* Why Sameer believes AI should support, not replace, clinicians

* How AI enhances diagnostic accuracy and clinician productivity

* The role of empathy and human connection in patient outcomes

Scaling Impact (33:11)

* NiaHealth’s vision to reach 100,000 Canadians by the end of next year

* Partnering with insurers and governments to expand preventative care

* Why a “built in Canada, for Canada” strategy is key to long-term success

About Sameer Dhar

Sameer Dhar is the Co-Founder and CEO of Nia Health, a serial entrepreneur and health-tech innovator recognized among Canada’s Top 20 Under 20 and Edmonton’s Top 40 Under 40. He previously founded Sensassure, an elder-care technology startup acquired by global health leader Essity.

Connect with Sameer Dhar on LinkedIn: https://www.linkedin.com/in/sameerdhar/

Visit the NiaHealth website: https://www.niahealth.co/

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/