Episode 73 of The Health Exchange Podcast explores the science and real-world impact of allergies, asthma, and type two inflammation with guest Payel Gupta, a triple board-certified physician in internal medicine, pediatrics, and allergy immunology. Dr. Rutland and Dr. Gupta break down how the immune system can mistakenly overreact to everyday triggers like pollen, pollution, foods, and pet dander, leading to chronic inflammation throughout the body. The conversation connects conditions like asthma, eczema, hay fever, food allergies, chronic sinus disease, and eosinophilic esophagitis through the lens of type two inflammation while explaining the role of immune signaling, environmental exposures, and modern allergy treatments. Dr. Gupta also shares the deeply personal story of losing her mother to a fatal asthma attack at age 12, how that experience shaped her career, and why allergic diseases are often dismissed despite their major impact on sleep, work, school, and quality of life. The episode also dives into anaphylaxis, epinephrine treatments, allergy immunotherapy, climate change’s effect on allergic disease, and why understanding inflammation is key to understanding the body itself.
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