June 02, 2026

The Link Between Creatine, Brain Health & Longevity

53 minutes

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Previous Episode - Two Fitness Tests Your Doctor Might Do Soon (start now!): Fitness is a Vital Sign

Next Episode - Why Certain Exercise Intensities Work for You (and Others May Not)

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There’s a growing science on creatine, brain health & longevity and may be one of the most important conversations midlife women need to hear right now.

Creatine is so much more than muscle — supports energy production, brain health, recovery, cognition, aging, sleep deprivation resilience, and why women in perimenopause and menopause may benefit even more than men.

The conversation also dives into the differences between creatine forms, misconceptions around bloating and kidney health, and why creatine may become one of the most important longevity supplements for midlife women

Tune in to learn why the research around creatine, brain health & longevity is creating so much excitement in the world of healthy aging.

My Guest:

Dr. Dan Pardi is the Chief Health Officer at Qualia Life Sciences, where he leads education to advance healthspan and peak performance. He’s the founder of humanOS.me and host of humanOS Radio, the official podcast of the Sleep Research Society. Dan has advised elite military units, Fortune 500 companies, and startups through his consultancy, Vivendi Health. He holds a PhD in Cognitive Neuroscience from Leiden University and Stanford, and speaks regularly at events like TEDx, VC Firms, and the Institute for Human Machine Cognition.

Questions We Answer in This Episode:

[00:06:00] What is creatine and what role does it play?

[00:08:20] How do you know if you need creatine and can you measure your levels?

[00:13:00] Creatine started out as a gym-bro supplement. What made it so popular in sports performance?

[00:16:34] What’s the link between creatine and the brain?

[00:28:10] How does creatine help cognitive performance during sleep deprivation?

[00:32:50] Why might creatine be even more beneficial for women than men?

[00:34:51] Should women adjust creatine intake during different phases of their cycle or perimenopause?

[00:37:49] What’s the difference between creatine monohydrate and creatine HCL?

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By Debra Atkinson

4.5

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