In part two of the series on the role of transplant for liver tumors, Alexander Parikh, MD, MPH, Chair of the SSO HPB Disease Site Work Group, is again joined by Ana Luiza Gleisner, MD, PhD, from the University of Colorado Anschutz Medical Campus in Aurora, CO and Shimul A. Shah, MD, MHCM, from the University of Cincinnati College of Medicine in Cincinnati, OH. They review the role of liver transplantation for malignancies of and to the liver. The discussion also covers the role of liver transplantation in the treatment of colorectal liver metastases including the impact of liver-directed therapies on the role of liver transplant.