The Sulfation pathway is often disrupted in children with autism. It is a major pathway in detoxification. It is also involved in a variety of biological processes including hormone regulation, molecular recognition, cell signaling, and the ability of viruses to enter cells. Molecular recognition is crucial in the body’s ability to bond to assist the ability of the immune system to recognize foreign agents to signal the immune system to respond accordingly, such as antigen-antibody, and strengthening protein interactions. People with autism tend to have difficulty with protein synthesis.

Damage to tissues in the body from oxygen is called oxidation. Mitochondria, the cells energy, and DNA, the genetic expression can be altered if too much oxidation exists without enough ANTI-oxidants. This disruption is known to alter the neuron pathways of the brain.

Glutathione is the body’s major anti-oxidant. Children with autism have low levels of glutathione which is compounded in the liver. The liver is the organ of detoxification and it is often congested in children with autism.  A cell’s ability to absorb, or “uptake” glutathione relies on multiple amino acids inside of cells. Reduced glutathione production inhibits the body’s ability to detoxify environmental toxins such as heavy metals, and contributes to the weakening of the lining of the digestive tract, also known as leaky gut. Leaky gut allows undigested food particles to enter the bloodstream causing the immune system to become over-responsive and create an allergic response to foods that may otherwise be harmless. Leaky gut also reduces the body’s ability to absorb the nutrients from the foods we eat.

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